无创正压通气联用纳络酮治疗煤工尘肺合并呼吸衰竭的疗效观察  

Observation on the clinical efficacy of non-invasive positive airway pressure ventilation combined with naloxone in patients of coal workers' pneumocoiosis complicated with respiratory failure

作　　者：何春来[1] 梁建业[1] 袁媛[1] 

机构地区：[1]北京京煤集团总医院,北京102300

出　　处：《中国医院药学杂志》2011年第15期1279-1280,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察无创正压通气和纳络酮联用于煤工尘肺合并呼吸衰竭患者的临床疗效。方法:71例煤工尘肺合并呼吸衰竭患者随机分为:甲组(传统常规综合治疗)、乙组(在甲组基础上加无创通气治疗)、丙组(在乙组基础上加纳络酮治疗),观察3组患者治疗前后pH、PaO2、PaCO2的变化。结果:治疗前3组的pH、PaO2、PaCO2无统计意义;治疗后3组的pH、PaO2、PaCO2与治疗前相比较差异有统计意义(P<0.05);乙组、丙组治疗后同一时间内的pH、PaO2、PaCO2与甲组相比较差异有统计意义(P<0.05);同一时间内丙组与乙组的pH、PaO2、PaCO2比较差异有统计意义(P<0.05)。结论:无创正压通气联用纳络酮治疗煤工尘肺合并呼吸衰竭比单用无创正压通气治疗效果更好,并且临床操作方便、安全,值得推广应用。OBJECTIVE To observe the clinical efficacy of non-invasive positive airway pressure ventilation combined in patients of coal workers＇ pneumocoiosis（cup） complicated with naloxone. METHODS 71 cases of CWP patients with respiratory failure were randomly divided into： Group A （traditional conventional combined therapy）, Group B （based on Group A plus the non-invasive positive pressure ventilation） and group C （based on Group B plus naloxone）, 3 groups were observed before and after treatment in patients with the changes of pH, PaO2, PaCO2 changes. RESULTS Before treatment, the pH, PaO2, PaCO2 of all the group were no statistical significance; after treatment the three group pH, PaO2, PaCO2 compared with that before treatment a statistically significant difference （P〈0. 05） ; Group B, Group C after treatment at the same time within the pH, PaO2, PaCO2 compared with Group A had statistically significant difference （P〈0. 05） ;Group C and Group B at the same time, the pH, PaO2, PaCO2 difference was statistically significant （P〈0. 05）. CONCLUSION Non-invasive positive airway pressure ventilation combined with naloxone for the treatment of CWP patients with respiratory failure is better than single treatment with non-invasive positive airway pressure ventilation, and the clinical manipulation is more convenient and safer. It is worthy for wide application.

关 键 词：无创通气 纳络酮 煤工尘肺 呼吸衰竭 

分 类 号：R969[医药卫生—药理学]