川西小黄菊醇提液对心肌缺血大鼠血流动力学的影响  

Effects of alcohol-extract of Pyrethrum tatsienense on hemodynamics of rats with myocardial ischemia injury

作　　者：严海英[1] 李永芳[1] 钱蔚[1] 

机构地区：[1]青海大学医学院药学系,青海西宁810001

出　　处：《华西药学杂志》2011年第4期354-355,共2页West China Journal of Pharmaceutical Sciences

基　　金：青海大学医学院资助项目(青医科技2009-002)

摘　　要：目的研究川西小黄菊醇提液(AEPT)对垂体后叶素致心肌缺血大鼠血流动力学的影响。方法采用大鼠舌下静脉注射垂体后叶素制备急性心肌缺血模型,观察AEPT对大鼠注射垂体后叶素后对血流动力学的影响。将大鼠随机分为模型组、阳性对照组和AEPT大、小剂量组,测定各组大鼠血流动力学指标的平均动脉压(MBP)、左心室收缩压(LVsP)、左心室舒张末压(LVEDP)、左心室等容期压力最大变化速率(±dp/dtmax)。结果 AEPT大、小剂量组大鼠的SBP、DBP、MBP、±dp/dtmax、LVSP均高于模型组;LVEDP则均低于模型对照组(P<0.05或P<0.01)。结论 AEPT对心肌缺血大鼠的心脏舒缩功能有一定的保护作用。OBJECTIVE To study the effects of alcohol-extract of Pyrethrum tatsienense（AEPT） on Pituitrin-induced myocardial injury in rats.METHODS A myocardial ischemia model of rats was established by intravenous injection with pituitrin.The experimental animals were randomly divided into the model group,positive control group and two does AEPT groups.The change of hemodynamics were observed,such as LVSP,±dp/dtmax,LVEDP and MBP.RESULTS Compared with the model group,the AEPT treated groups showed higher SBP,DBP,MBP,±dp/dtmax,LVSP,but lower LVEDP（P0.05 and P0.01）.CONCLUSION These results suggested that the AEPT was able to protect cardiac dysfunction caused by pituitrin-induced myocardial ischemia in rats.

关 键 词：川西小黄菊 心肌缺血 垂体后叶素 血流动力学 

分 类 号：R96[医药卫生—药理学]