盐酸美金刚胺前药MeN-1和MeN-2在人工胃肠液中的稳定性研究  

Study on the stability of the prodrug of Memantine hydrochloride MeN-1 and MeN-2 in the artificial gastric juice and the artificial intestinal juice

作　　者：肖瑶[1] 曹俊涵[1] 赵书文[1] 蒋德锡[1] 张丹[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2011年第4期389-390,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的考察盐酸美金刚胺前药MeN-1和MeN-2在人工胃肠液中的稳定性。方法采用HPLC法测定盐酸美金刚胺前药MeN-1和MeN-2在人工胃液和人工肠液中的浓度,并比较两者的稳定性。结果 MeN-1在人工胃液中孵育3 h后,其相对含量为90%,但在人工肠液中降至约70%;而MeN-2在人工胃肠液中孵育1 h后,其相对含量均降至90%以下。结论在人工胃液中,MeN-1较MeN-2稳定,表明MeN-1更适于开发为口服制剂。OBJECTIVE To investigate the stability of the prodrugs of Memantine hydrochloride-MeN-1 and MeN-2 in the artificial gastric juice（AGJ） and the artificial intestinal juice（AIJ）.METHODS An HPLC method was established to determine the concentration of the prodrugs of Memantine hydrochloride-MeN-1 and MeN-2 in the AGJ and the AIJ.Inaddition the stability of MeN-1 and MeN-2 was compared.RESULTS 90% of MeN-1 was left after 3 hours in AGJ and 70% was left afer 3 hours in AIJ.While less than 90% of MeN-2 was left afer 1 hours in both artificial juices.CONCLUSION Compared with MeN-2,MeN-1 was more stable in AGJ.Therefore that MeN-1 was fit for the oral preparations.

关 键 词：盐酸美金刚胺 前药 MeN-1 MeN-2 人工胃液 人工肠液 稳定性 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学]