乳腺癌化疗患者24小时动态心电图分析  

Analysis of 24 Hours Cardiac Arrhythmia and Heart Rate Variability in Chinese Breast Cancer Chemotherapy Patients

作　　者：杨兴艳[1] 李成燕[1] 孙贵红[1] YANG Xing-yan,LI Cheng-yan,SUN Gui-hong（Department of electrocardiogram,Affiliated Hospital of Zunyi Medical College,Zunyi 563003,China）

机构地区：[1]遵义医学院附属医院心电图科,贵州遵义563003

出　　处：《医学信息》2011年第16期5343-5345,共3页Journal of Medical Information

摘　　要：目的观察乳腺癌化疗患者的动态心电图改变及HRV影响,探讨乳腺癌化疗患者心脏自主神经功能的平衡情况。方法对38例乳腺癌化疗患者,并以38例乳腺癌未作化疗患者作对照,进行24h动态心电图检查,分析24h心律失常,对其时域结果进行分析。结果与对照组相比,化疗组大部分时域指标均明显降低（P〈0.05）,化疗组各类心律失常发生率明显高于对照组（P〈0.05）。结论动态心电图是评价乳腺癌化疗患者心脏植物神经功能状况的有效检测手段,对评价乳腺癌患者是否合并有心脏损害具有一定的临床指导意义。Objective To investigate the occurrence of arrhythmias and the heart rate variability（HRV） in Chinese Breast Cancer Chemotherapy Patients,and to explore the balance of autonomic nervous function.Methods 12 lead 24h ambulatory electrocardiography were performed in 38 Chinese Breast Cancer Chemotherapy Patients,and 38 healthy controls.We observed arrhythmias in 24h and analyzed 24h time-domain HRV.Results Most of time-domain decreased in group Breast Cancer Chemotherapy Patients,comparedwith the control group（P0.05）,the occurrence of arrhythmias in Breast Cancer Chemotherapy groups is increase significantly compare with control group（P0.05）.Conclusions The Breast Cancer Chemotherapy Patients,with arrhythmias may be related with balance reduction of autonomic nervous function,the decrease the indexes of HRV and then relieve the vagus nervous tension and increase the sympathetic nervous tension,which could bring high risk of cardiogenic sudden death and malignant arrhythmia.These influences were more obvious in patients with the Breast Cancer Chemotherapy Patients.Therefore,we should pay more attention to these affects and treat patients effectively.

关 键 词：乳腺癌 化疗 心率变异 心律失常 植物神经功能 

分 类 号：R540.41[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]