黄芪有效部位对化疗性贫血小鼠细胞因子IL-2、IL-4、IL-6的影响  

Effect of Effective Parts of Astragalus on Cytokines IL-2 IL-4 and IL-6 of Chemotherapy-induced Anemic Mice

作　　者：陈晶晶[1] 范颖[1] 张红梅[1] 林庶茹[2] 

机构地区：[1]辽宁中医药大学方剂学科,辽宁沈阳110032 [2]辽宁中医药大学中医分子生物实验室,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2011年第8期77-79,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然基金项目(30873232);辽宁省优秀人才项目(2009R39)

摘　　要：目的:探讨黄芪有效部位对化疗性贫血模型小鼠脾组织IL-2、IL-4、IL-6的影响。方法:采用ELISA法测定脾组织IL-2、IL-4、IL-6含量。结果:模型组脾组织IL-2、IL-4含量下降,IL-6含量升高,均有统计学意义(P<0.05)。各治疗组对化疗所致骨髓抑制性贫血的脾组织IL-2、IL-4、IL-6具有不同程度的调控作用。结论:IL-2、IL-4、IL-6与环磷酰胺所致骨髓抑制性贫血的免疫失调有关;黄芪及其有效部位对环磷酰胺引起的骨髓抑制性贫血引发的免疫损伤具有保护作用,并对IL-2、IL-4、IL-6的生成具有不同的调节机制。Objective：To investigate effect of effective parts of astragalus on cytokines IL-2,IL-4 and IL-6 of chemotherapy-induced anemic mice.Methods：Enzyme-linked immunosorbent assay（ELISA） was applied to measure the content of IL-2,IL-4 and IL-6 in spleen.Results：In spleen of the model group,the content of IL-2 and IL-4 decreased,the content of IL-6 increased,both with significances in statistics（P〈0.05）.In each treated group,IL-2,IL-4 and IL-6 in spleen of chemotherapy-induced myelosuppression anemic mice are regulated in varying degree.Conclusion：There are relationship between immune disorders caused by cyclophosphamide-induced myelosuppression anemia and the content of IL-2,IL-4 and IL-6.Astragalus and its effective parts can protect immune injury caused by cyclophosphamide-induced myelosuppression anemia,also regulate the production of IL-2,IL-4 and IL-6 in different metabolism.

关 键 词：黄芪 有效部位 环磷酰胺 贫血模型 细胞因子 

分 类 号：R282.71[医药卫生—中药学]