幽门螺杆菌感染及非甾体抗炎药致消化性溃疡并出血的相关性研究  

Association studies of Helicobacter pylori and non-steroidal anti-inflammatory drugs in patients with bleeding peptic ulcer

作　　者：王莹[1] 王秀英[1] 王敏琴[1] 

机构地区：[1]黑龙江省大庆油田总医院消化内科,黑龙江大庆163001

出　　处：《中华医院感染学杂志》2011年第16期3411-3412,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨服用非甾体抗炎药及幽门螺杆菌感染与消化性溃疡并出血的相关性。方法对188例消化性溃疡患者的临床资料进行回顾性分析,将其所有的危险因素行单因素和多因素分析。结果在单因素分析中,出血组中年龄≥60岁、既往有消化道出血史、心脑血管史、口服非甾体抗炎药所占比例高于未出血组,两组比较差异有统计学意义(P<0.05);进一步行多因素logistic回归分析,发现年龄≥60岁、既往有消化性溃疡史、消化道出血史、心脑血管病史、单纯Hp感染、单纯服用非甾体抗炎药及Hp感染+服用非甾体抗炎药均为消化性溃疡并出血的危险因素(P<0.01)。结论单纯Hp感染并不能增加消化性溃疡并出血的危险性,但若与年龄≥60岁、服用非甾体抗炎药、既往有消化性溃疡史、消化道出血史、心脑血管史等因素同时出现可增加其危险性。OBJECTIVE To explore the association studies of Helicobacter pylori and non-steroidal anti-inflammatory drug in patients with bleeding peptic ulcer.METHODS The clinical dates of 188 cases of peptic ulcer were reviewed retrospectively.Each parameters were evaluated with univariate and multivariate analysis.RESULTS Univariate analysis identified 4 statistically significant variables,including aged ≥60 years,the history of peptic ulcer,cardio cerebral vascular diseases and NSAIDs use（P0.05）.Logistic regression analysis showed that aged 60 years,the history of peptic ulcer,bleeding peptic ulcer and cardio cerebral vascular diseases,H.pylori infection alone,NSAIDs alone and combined H.pylori infection and NSAIDs were the risk factors of bleeding peptic ulcer（P0.01）.CONCLUSION H.pylori infection is not a risk factor for bleeding peptic ulcer,but combination of aged 60 years,H.pylori,the history of peptic ulcer,bleeding peptic ulcer and cardio cerebral vascular diseases increases in risk factors of bleeding peptic ulcer.

关 键 词：幽门螺杆菌 非甾体抗炎药 消化性溃疡 相关性研究 

分 类 号：R181.32[医药卫生—流行病学]