医院普外科感染铜绿假单胞菌的耐药性  

Antimicrobial resistance of Pseudomonas aeruginosa causing nosocomial infection in department of general surgery

作　　者：王群兴[1,2] 叶湘[1,3] 何晓雯[1,2] 余良芳[1,2] 周宜兰[1,2] 

机构地区：[1]三峡大学第一临床医学院 [2]宜昌市中心人民医院检验科,湖北宜昌443003 [3]宜昌市中心人民医院产科,湖北宜昌443003

出　　处：《中华医院感染学杂志》2011年第16期3491-3492,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨医院普外科感染铜绿假单胞菌（PAE）的耐药特性,为临床医师合理用药提供科学依据。方法细菌培养和菌株鉴定严格按照《全国临床检验操作规程》进行,采用CLSI推荐的K-B法进行药敏试验和判断结果。结果普外科158株PAE对亚胺培南、美罗培南、阿米卡星、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦耐药率较低,在11.4%~14.6%;耐药率最高的抗菌药物是磺胺甲噁唑/甲氧苄啶,为60.1%;PAE泛耐药菌株检出15株,检出率为9.5%。结论检验科临床微生物室应对细菌耐药性进行动态监测和定期公示,有效控制多药耐药细菌医院感染。OBJECTIVE To investigate antimicrobial resistance of Pseudomonas aeruginosa（PAE） causing nosocomial infection in department of general surgery in our hospital and provide the scientific evidence for clinically reasonable use of antibiotics.METHODS Referring to National Guide to Clinical Laboratory Procedures,the bacterial culture and identification were performed.The susceptibility testing was performed by K-B methods recommended by CLSI.RESULTS Among 158 isolates of PAE,resistance rates of imipenem,meropenem,amikacin piperacillin/tazobactam and cefoperazone/sulbactam were the lowest,arriving at 11.4%-14.6%.The resistance rate of trimethoprim-sulfamethoxazole（60.1%） was the highest.The detection rate of pan-resistant PAE was 9.5%.CONCLUSIONS The microbiologists in department of clinical laboratory should monitor dynamically and publish regularly the bacterial drug resistance to control multiresistant strains causing nosocomial infection.

关 键 词：普外科 铜绿假单胞菌 医院感染 耐药性 合理用药 

分 类 号：R378.991[医药卫生—病原生物学]