不同年龄人群感染铜绿假单胞菌及其耐药率的比较  

Pseudomonas aeruginosa infections in different age groups and comparison of drug resistance

作　　者：刘宇[1] 甘慧泉[2] 徐坤[1] 徐君[1] 

机构地区：[1]暨南大学第一附属医院ICU,广东广州510630 [2]广东省医学科学院广东省人民医院病理医学部检验科,广东广州510080

出　　处：《中华医院感染学杂志》2011年第16期3493-3495,共3页Chinese Journal of Nosocomiology

摘　　要：目的及时了解不同年龄人群感染铜绿假单胞菌（PAE）及其耐药情况,指导临床合理使用抗菌药物。方法回顾性调查医院2007-2009年从临床各不同年龄人群分离的1162株PAE,及对18种常规抗菌药物的耐药结果,并进行统计分析。结果感染人群比较集中于ICU,占11.36%-25.00%;感染标本来源最多的是痰,占32.65%-60.61%;分离自〈18岁患者的PAE对氨曲南、环丙沙星、左氧氟沙星的耐药率分别为15.97%、1.82%、0.84%;40-60岁人群的PAE对头孢曲松的耐药率为48.73%,均较其他年龄人群的耐药率低,差异有统计学意义（P〈0.05）。结论临床应加强细菌耐药监测,针对不同人群合理使用抗菌药物,减少细菌耐药的发生。OBJECTIVE To explore the resistance of Pseudomonas aeruginosa（PAE） isolated from different ages and provide the guidance for the clinical treatment.METHODS Retrospective survey of 1162 strains of PAE from different ages from 2007 to 2009 was carried out and the resistance to 18 commonly used antiseptic drugs was statistically analyzed.RESULTS The infected people mainly come from ICU（11.36%-25.00%）.Most isolates were from sputum（32.65%-60.61%）.The resistance rates to aztreonam,ciprofloxacin,levofloxacin PAE from the aged 0-18 were 15.97%,1.82%,0.84%,respectively.which were lower than others（P0.05）;The resistance rate to ceftriaxoneof PAE from 40-60 was 48.73%,which was lower than the other age groups,the differences were statistically significant.CONCLUSION The clinical departments should strengthen the surveillance to susceptibility of all bacteria,and the antibiotics should be rationally used according to different age groups so as to reduce bacterial resistance.

关 键 词：铜绿假单胞菌 不同年龄 抗菌药物 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]