IL-2对感染不同株旋毛虫小鼠的免疫调节作用  

IMMUNOREGULATION OF IL-2 IN TRICHINELLA\|INFECTED MICE

作　　者：牛春[1] 姜洪杰[1] 黄松[1] 诸欣平[1] 

机构地区：[1]首都医科大学细胞生物系,北京100054

出　　处：《中国寄生虫学与寄生虫病杂志》1999年第6期374-376,共3页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：美国中华医学基金会(CMB)资助!项目(No.98-647)

摘　　要：目的： 探讨细胞因子在旋毛虫感染免疫中的调节作用。方法： 采用间接ＥＬＩＳＡ 和生殖力指数测定等方法对ＩＬ－２ 作用下感染旋毛虫小鼠的ＩｇＧ抗体水平及寄生虫感染力进行连续观察。结果： 不同剂量ＩＬ－２对不同地理株感染小鼠产生的影响存在较大差异： 对于黑龙江株猪型旋毛虫感染小鼠， ＩＬ－２ 注射具有明显抗虫效果； 而对于美国株猪型旋毛虫感染的小鼠， ＩＬ－２ 对成虫繁殖力无显著影响， 但大剂量ＩＬ－２ （每鼠２ ０００ Ｕ／次） 使新生幼虫的感染力降低。结论： ＩＬ－２ 对黑龙江株猪型旋毛虫感染力有明显抑制作用。AIM: To study the immunoregulation of IL\|2 in Trichinella\|infected mice. METHODS: Mice infected respectively with HL strain and AM strain larvae of Trichinella spiralis were treated ip with IL\|2 from the second day postinfection for 3 days. Serum IgG antibody levels were determined by ELISA and the infection capacity was determined using reproductive capacity index (RCI). RESULTS: In HL, higher dosage of IL\|2 injection induced lower RCI and showed apparent anti\|Trichinella effect. In AM, both low and high dose of IL\|2 had no measurable effect on RCI, however, high dose of IL\|2 reduced the infectivity of newborn larvae. CONCLUSION: IL\|2 exhibits apparent suppressive effect on the infectivity of T.spiralis of HL strain.\;

关 键 词：旋毛虫病 白细胞介素2 IGG抗体 免疫调节 

分 类 号：R532.14[医药卫生—内科学]