PDGF-B链基因表达的调控及其在常见心血管疾病中的意义  

The regulation of PDGF B-chain gene expression and its significance in common cardiovascular diseases

作　　者：沈传陆[1] 

机构地区：[1]中国医学科学院基础医学研究所

出　　处：《中国病理生理杂志》1999年第12期1138-1141,共4页Chinese Journal of Pathophysiology

摘　　要：PDGF B-chain, a component of platelet-derived growth factor (PDGF), is encoded by PDGF B-chain gene. Recently, the transcriptional regulation of PDGF B-chain gene has been studied extensively. Some cisacting elements in the gene and some relevant trans-acting factors have been identified. Some research data demonstrated that the transcriptional regulation of PDGF-B chain gene was uncommon during some common cardiovascular diseases. The molecular mechanisms underlying the pathogenic factors-mediated transcription of the gene are begining to be understood, which will open a good respect for prevention and treatment of the common cardiovascular diseases.PDGF B-chain, a component of platelet-derived growth factor (PDGF), is encoded by PDGF B-chain gene. Recently, the transcriptional regulation of PDGF B-chain gene has been studied extensively. Some cisacting elements in the gene and some relevant trans-acting factors have been identified. Some research data demonstrated that the transcriptional regulation of PDGF-B chain gene was uncommon during some common cardiovascular diseases. The molecular mechanisms underlying the pathogenic factors-mediated transcription of the gene are begining to be understood, which will open a good respect for prevention and treatment of the common cardiovascular diseases.

关 键 词：心血管病 PDGF-B链 基因表达 基因调控 

分 类 号：R541.02[医药卫生—心血管疾病]