普鲁卡因胺对肺血栓栓塞及6-酮-前列腺素F1α和血栓素B_2生成的影响  

Effects of procainamide on the pulmonary thromboembolism and the production of 6-keto-prostaglandin F1α and thromboxane B_2

作　　者：林继红[1] 单春文[2] 顾为望[1] 

机构地区：[1]第一军医大学实验动物中心,广州510515 [2]第一军医大学药理教研室,广州510515

出　　处：《第一军医大学学报》1999年第5期429-430,434,共3页Journal of First Military Medical University

摘　　要：目的研究普鲁卡因胺抗血栓及其作用机理。方法给小鼠注射胶原和肾上腺素混合液，制造肺血栓模型，用放免法测定６－ｋｅｔｏ－ＰＧＦ１ａ和ＴＸＢ２含量。结果普鲁卡因胺５ｍｇ／ｋｇ，１０ｍｇ／ｋｇ和２０ｍｇ／ｋｇ使小鼠的幸存率增加３３．３％－８０.０％；使６－ｋｅｔｏ－ＰＧＦ１ａ的产量提高７０.８％－２２３.９％；而同时抑制ＴＸＢ_２的产生，抑制率为２０．５％－４４.７％，６－ｋｅｔｏ－ＰＧＦ１ａ与ＴＸＢ_２的比值明显提高，对照组为１.２，药物组为２．６，４.０和７.１。结论普鲁卡因胺具有明显的抗肺血栓作用，其作用与６-ｋｅｔｏ-ＰＧＦ１ａ和ＴＸＢ_２的比值增加有关。Objective To study antithrombosis and its mechanism by procainamide. Methods Thrombosis was induced by injecting amixture containing collagen and adrenaline into the tail vein. Radioimmunoassay was used to examine the level of 6-ketoprostaglandin F1α(6-keto-PGF1α) and thromboxane B_2(TXB_2). Results The survival % increased by 33.3% to 80%, the level of 6keto-PGF1a increased by 70.8% - 223.9%, and the product of TXB_2 decreased by 20.3%-44.7% by procainamide 5, 10 and 20mg/kgin mice. The ratios of 6-keto-PGF1a to TXB_2 enhanced markedly in which the ratios were 1.2(control group). 2.6, 4.0 and 7.1(druggroup). Conclusion Procainamide inhibited markedly pulmonary thromboembolism and its mechanism is relative to the ratio of 6keto-PGF1α to TXB2.

关 键 词：普鲁卡因胺 肺前塞 血栓素B2 6-Kdto-pGF12 

分 类 号：R563.5[医药卫生—呼吸系统] R973.2[医药卫生—内科学]