糖尿病与胆囊排空障碍  

Diabetes and impaired gallbladder emptying

作　　者：高方[1] 周华[2] 穆红霞 汪吉仪[1] 程天明 

机构地区：[1]第一军医大学南方医院,广州510515 [2]第一军医大学超声科,广州510515 [3]第一军医大学外科教研室,广州510515 [4]第一军医大学消化科,广州510515

出　　处：《第一军医大学学报》1999年第5期449-450,共2页Journal of First Military Medical University

摘　　要：目的探讨糖尿病患者胆囊的运动功能。方法用超声对比观察２２例正常对照和２０例糖尿病人空腹胆囊大小、状态及脂肪餐后胆囊收缩半排空时间的差异。对其中６例有明显胆囊排空障碍的病人，给予西沙比利１０ｍｇ，３次／ｄ治疗４周后复查。结果正常对照与糖尿病组餐前胆囊面积无差异，但糖尿病人胆结石形成率高达３０％（６／２０），胆囊壁增厚、粗糙率为３５％（７／２０），明显高于正常对照组（Ｐ＜００５），餐后的胆囊半排空时间正常对照组为（２７±４．４）ｍｉｎ，而糖尿病组为（４６１±１２９）ｍｉｎ，（Ｐ＜０.０５）。６名有排空障碍的糖尿病患者治疗前的半排空时间为（５８．３±４．１）ｍｉｎ，经治疗后半排空时间为（３０±６．３）ｍｉｎ，（Ｐ＜０．０１）。结论糖尿病患者有明确的胆囊排空运动障碍，并较多发生胆囊炎、胆石症，西沙经利可有效改善糖尿病患者的胆囊排空障碍。Objective To investigate the gallbladder contractile function in diabetic patents. Methods The gallbladder size and shapewere scanned prior to the breakfast and the half time (HET) of the emptying gallbladder was recorded after the fatty meal byultrasonography in 20 diabetic patients and 22 healthy subjects. 6 diabetic patients with impair gallbladder emptying receivedcisapied (10 mg, po, tid) and were reexamined at the end of 4 weeks. Results No significant difference was note between the patientsand healthy subjects in gallbladder fasting. However, the lithogenesis rate and the incidence of gallbladder wall thickening androughing were higher (30% and 35%. respectively) in the patients than the subjects (P<0.05). The HET after fatty meal was longerin the patients than in the subjects (46.1±12.9 vs 27.0±4.4 min, P<0.05). The HET was shorten from 58.3±4.1 to 30.0±6.3 min(P<0.01) in these 6 patients after cisapride therapy. Conclusion These results indicate the gallbladder contractile dysfunction,cholecystitis and cholelithiasis are common in diabetic patients, and cisapride can effectively improve gallbladder contractilefunction in diabetic patients.

关 键 词：粮尿病 胆囊运动 胆囊排空障碍 

分 类 号：R587.2[医药卫生—内分泌] R575.6[医药卫生—内科学]