高糖摄入对大鼠血压及糖代谢的影响  

THE EFFECTS OF HIGH SUCROSE INGESTION ON BLOOD PRESSURE AND GLUCOSE METABOLISM IN RATS

作　　者：陈祥鸿[1] 武军[2] 韩宝亭 

机构地区：[1]青岛医学院附属医院心内科,青岛266003 [2]青岛医学院诊断学教研室 [3]平度市人民医院心内科

出　　处：《青岛医学院学报》1999年第4期247-249,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的　观察高糖摄入对正常Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ（ＳＤ）大鼠血压、糖及胰岛素代谢的影响。②方法将雄性ＳＤ大鼠１６只随机分为２组，实验组于饮水中添加蔗糖（１２０ｇ／Ｌ）喂养４２ｄ，对照组给以正常饮水，每７ｄ 定时测量体质量（ＢＷ）、收缩压（ＳＢＰ）及心率（ＨＲ），实验最后１ｄ 取血测定空腹血糖（ＦＢＧ）和血清胰岛素（ＩＮＳ）等。③结果　自第８ 天起，实验组ＳＢＰ及ＨＲ即高于对照组，并持续至实验结束（ｔ＝ ２．１８～５．６０，Ｐ均＜ ０．０５，０．０１）；与对照组相比，实验组ＦＢＧ水平升高（ｔ＝ ２．７５，Ｐ＜ ０．０５）；两组空腹血清ＩＮＳ水平虽然无显著性差别（ｔ＝ ０．７７，Ｐ＞０．０５），但是经协方差分析纠正体质量因素后，实验组与对照组相比存在高胰岛素血症（Ｆ＝ ７．３３，Ｐ＜ ０．０５）；直线相关分析提示，实验组ＩＮＳ水平与ＢＷ 及ＳＢＰ呈高度正相关，对照组中ＩＮＳ水平亦与ＢＷ 呈高度正相关（ｒ＝ ０．７５６～０．９１５，Ｐ均＜ ０．０５，０．０１）。④结论　高糖摄入可显著升高正常ＳＤ大鼠的血压及ＦＢＧ，而胰岛素代谢紊乱可能在其中起重要作用。Objective\ To investigate the effects of high sucrose ingestion on blood pressures and glucose/insulin metabolism in Sprague Dawley(SD) rats.\ Methods\ Sixteen male SD rats were randomly divided into two groups: control(C, n =8) and sucrose(S, n =8). The rats in the S group were given sucrose(120g/L) dissolved in tap water as drinking water for 42 days, while the rats in the C group were given tap water. Measurements of systolic blood pressure(SBP), heart rate(HR) and body weight(BW) were conducted every seven days. The levels of fast blood glucose (FBG) and serum insulin (INS) were measured by taking blood samples after 5 hour fasting on the last day of the experiment.\ Results\ The S group exhibited hypertension and tachycardia compared with the C group from the 8th day to the end of the experiment( t=2.18-5.60,P <0.05,0.01). The S group also exhibited hyperglycermia( t=2.75,P <0.05). The insulin levels showed positive correlation with SBP and BW in the S group and with BW in the C group( r=0.756-0.915,P <0.05,0.01). Although the INS levels of fast serum in both groups had no obvious difference( t=0.77,P >0.05), when the factors of BW were corrected by using analysis of covariance, the S group exhibited hyperinsulinemia compared with the C group( F=7.33,P <0.05).\ Conclusion\ The development of perturbations in glucose/insulin metabolism such as insulin resistance and/or hyperinsulinemia may play important role in sucrose induced hypertension in SD rats.\;

关 键 词：高血糖症 血压 胰岛素 大鼠 糖代谢 

分 类 号：R589.102[医药卫生—内分泌]