成都地区中老年居民脉压及脉压指数与高尿酸血症关系研究  

An Analysis of the Relationship between Pulse Pressure,Pulse Pressure Index and Hyperuricemia in Middle-aged and Aged Residents in Chengdu

作　　者：吴凯[1,2] 王斯[1] 陈晓平[1] 高音[2] 陈小妮 张昕[1] 何森[1] 刘凯[1] 吕政兵[1] 

机构地区：[1]四川大学华西医院心内科,成都610041 [2]九○三医院心内科

出　　处：《华西医学》2011年第7期1010-1013,共4页West China Medical Journal

基　　金：国家"十一五"科技支撑项目(2006BAI01A01)~~

摘　　要：目的分析成都地区中老年居民脉压(pulse pressure,PP)及脉压指数(pulse presure index,PPI)与高尿酸血症(hyperuricemia,HUA)的关系。方法利用2007年5月代谢综合征研究调查资料(共1 061人),依据PP[≤60mm Hg(1mm Hg=0.133kPa)、>60mm Hg]和PPI(≤0.450、>0.450)将人群分为正常组及增高组,分析两组人群尿酸水平及HUA患病率,采用单因素回归及logistic回归分析PP及PPI与HUA关系。结果①PP/PPI增高组血浆尿酸水平明显高于PP/PPI正常组,差异有统计学意义(P=0.000)。②PP/PPI增高组HUA患病率明显高于PP/PPI正常组,差异有统计学意义(P=0.026、0.027)。③单因素回归和logistic回归分析皆提示PP及PPI与HUA呈正相关。结论成都地区PP及PPI与血浆尿酸水平关系密切,PP/PPI增高可能是HUA的危险因素。Objective To evaluate the relationship between pulse pressure（PP）,pulse pressure index（PPI） and hyperuricemia（HUA） among middle-aged and aged residents in Chengdu.Methods Based on the level of PP [≤60 mm Hg（1 mm Hg=0.133 kPa）,60 mm Hg] and PPI（≤0.450,0.450）,We divided the 1 061 middle-aged or aged people into normal PP/PPI group and augmented PP/PPI group.All patients came from the survey for metabolic syndrome study in May 2007.We analyzed the distribution of serum uric acid（UA） and HUA,and analyzed the relationship between PP,PPI and HUA by using single-factor and logistic regression analysis.Results The index of UA in the augmented PP/PPI groups was higher than that in the normal groups with a significant difference（P=0.000）.The prevalence of HUA in the augmented PP/PPI groups was statistically higher than that in the normal groups（P=0.026,0.027）.Single-factor and logistic regression analysis showed that PP and PPI were both positively correlated to HUA.Conclusion The abnormalities of PP and PPI are closely related to metabolism disorder in Chengdu,and high level of PP or PPI is probably risk factors for HUA.

关 键 词：脉压 脉压指数 收缩压 舒张压 尿酸 高尿酸血症 

分 类 号：R589[医药卫生—内分泌]