化妆品变应性接触性皮炎变应原检测分析  

Detection of causative allergens of cosmetic allergic contact dermatitis

作　　者：蔡永莲[1] 刘润秋 施辛[1] 张静[1] 黎平[1] 

机构地区：[1]苏州大学附属第二医院皮肤科,215004 [2]盐城市第一人民医院

出　　处：《中华皮肤科杂志》2011年第8期586-589,共4页Chinese Journal of Dermatology

摘　　要：目的调查化妆品变应原种类，为化妆品过敏提供流行病学资料和临床依据。方法对89例门诊疑诊化妆品变应性接触性皮炎患者采用49种欧洲化妆品系列变应原及5种中国筛查系列化妆品变应原进行斑贴试验，按国际接触性皮炎研究组推荐标准判读结果。结果89例患者中，61例对1种或1种以上化妆品变应原过敏，阳性反应率68．5％。其中阳性率较高的有香料33．7％，防腐剂30．3％，对苯二胺25．8％，阿莫醇10．1％。结论香料、防腐剂、对苯二胺、阿莫醇等是化妆品变应性接触性皮炎患者的主要致敏原。Objective To make a survey on common cosmetic allergens, and to provide epidemiological data and clinical evidence for cosmetic allergy. Methods Patch test was performed by using 49cosmetic allergens from a European cosmetic series and 5 Chinese standard screening allergens on 89patients with suspected cosmetic allergic contact dermatitis. Test results were determined according to the International Contact Dermatitis Research Group (ICDRG) recommendation. Results Of the 89 patients, 61(68.5%) showed positive reactions to one or more cosmetic allergens. The most common allergens were fragrances (33.7%), followed by preservatives (30.3%), para-phenylenediamine (25.8%) and amerchol L 101(10.1%). Conclusion Fragrances, preservatives, para-phenylenediamine and amerchol L 101 are dominant causative allergens in patients with cosmetic allergic contact dermatitis.

关 键 词：变应性接触性皮炎 化妆品过敏 变应原 检测分析 流行病学资料 对苯二胺 斑贴试验 阳性率 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]