DNA疫苗的运送载体——减毒霍乱沙门氏菌  

Attenuated Salmonella choleraesuis as DNA vaccine vector

作　　者：惠锋明[1] 茆达干[1] 蒋进[1] 

机构地区：[1]南京农业大学动物科技学院动物繁殖研究室,210095

出　　处：《免疫学杂志》2011年第8期722-725,共4页Immunological Journal

基　　金：中农南农青年教师开放基金(NC2008005)

摘　　要：霍乱沙门氏菌是人兽共患病原菌,遗传背景清楚,利用它作为载体表达外源抗原基因已得到较广泛的研究并取得了一定的效果。本文从沙门氏菌的侵入途径、减毒重组菌对基因疫苗的呈递及诱发免疫应答的机制、作为载体的优势以及免疫存在的问题等方面就减毒霍乱沙门氏菌作为运送DNA疫苗的载体作简要概述。Salmonella choleraesuis is one of the pathogens that can be transmitted between human and animals.Its genetic background is clear.As a DNA vaccine vector,it has been widely used to express various antigens and certain results have been achieved.This review gives a brief introduction of attenuated Salmonella choleraesuis as DNA vaccine vector,including the invasion way,the mechanism for processing genetic vaccine and inducing immune responses,the advantages and limitations.

关 键 词：减毒沙门氏菌 霍乱沙门氏菌 基因免疫 

分 类 号：R392[医药卫生—免疫学]