促进脂肪组织工程再血管化的相关研究进展  

ADVANCE OF REVASCULARIZATION OF ADIPOSE TISSUE ENGINEERING

作　　者：常强[1] 潘世杰[1] 鲁峰[1] 

机构地区：[1]南方医科大学南方医院整形外科,广州510515

出　　处：《中国修复重建外科杂志》2011年第8期1008-1013,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(30901566);广东省自然科学基金资助项目(9151051501000025)~~

摘　　要：目的对脂肪组织工程中再血管化的研究现状进行分析,为组织工程脂肪再血管化提供理论参考。方法广泛查阅近年有关脂肪组织工程中关于再血管化研究的相关文献,围绕促血管化的5个方面,包括脂肪细胞组织结构及血供系统的特殊性、血管化的机制、种子细胞的复合、支架材料的修饰、微环境的改善,进行相关文献复习和综述。结果脂肪组织工程技术为修复软组织缺损提供了一条新思路,但目前构建成功的组织工程脂肪体积均未超过1 mL,主要与构建物内血管化程度有关,因此构建物内血供的快速重建是脂肪组织工程由基础向临床应用的关键性环节。结论促进脂肪组织工程移植物尽快再血管化,能使支架上种子细胞及时获得营养,为制备大体积组织工程脂肪提供可能,从而满足临床修复大范围软组织缺损的需要。Objective To review the research status of the neovascularization of adipose tissue engineering in the past decade so as to provide theoretical references for the development of the rapid revascularization of tissue engineered adipose. Methods The literature about the revascularization of adipose tissue engineering was extensively reviewed and analyzed, centering on 5 elements： specificity of histological structures and blood supply, revascularization mechanism, coculture of different seed cells, modification of scaffold, and microenvironment. Results Adipose tissue engineering offers a new solution for soft tissue defects. However, there is still the unfulfilled need in the size of engineered adipose tissue （less than 1 mL）, which was determined by the degree of neovascularization in engineered tissue. Overall, rapid neovascularization in engineering tissue is a key link of experimental study changing into clinical application. Conclusion Providing a sufficient supply with nutrients and oxygen by means of a sufficient and rapid neovascularization will be at the heart of any attempts to obtain bigger tissue engineered adipose to meet the demand of repairing large soft tissue defect.

关 键 词：脂肪组织工程 再血管化 种子细胞 支架材料 

分 类 号：R622[医药卫生—整形外科]