舒芬太尼用于肝叶切除术全凭静脉麻醉的随机双盲临床观察  

Comparison of sufentanil and fentanyl in total intravenous anesthesia for liver resection： A double blind randomized clinical trial

作　　者：肖锋[1] 李晋[1] 徐军美 

机构地区：[1]中南大学湘雅二医院麻醉科,长沙410011

出　　处：《中国医师杂志》2011年第7期917-918,922,共3页Journal of Chinese Physician

摘　　要：目的比较舒芬太尼与芬太尼应用于肝叶切除术全凭静脉麻醉术中血流动力学变化，术后苏醒的速度与质量及常见并发症发生率。方法选取100例择期行肝叶切除手术的患者，按数字随机表法分为两组：舒芬太尼组（S组），芬太尼组（C组），每组50例。记录术中心率及平均动脉压等血流动力学数据，患者睁眼时间及拔管时间，术后视觉疼痛评分（VAS）以及术后恶心呕吐、呼吸抑制、躁动等并发症发生率。结果与芬太尼组比较，舒芬太尼组患者术中血流动力学较平稳，患者睁眼时间及拔管时间差异无统计学意义（P〉0．05），术后VAS评分较低（S组4．2±1．1，C组6．1±1．2），术后躁动（S组2例，C组11例）及呼吸抑制（S组1例，C组5例）的发生率低，恶心呕吐及苏醒延迟的发生率差异无统计学意义（P〉0．05）。结论舒芬太尼用于肝叶切除术全凭静脉麻醉术中血流动力学稳定，术后疼痛较轻，术后躁动及呼吸抑制发生率较低。Objective To compare fentanyl and sufentanil in total intravenous anesthesia for liver resection. Methods 100 patients undergoing liver resection were randomly received either sufentanil （ group S, n = 50） anesthesia or fentanyl （ group C, n = 50）. Hemodynamic variables, time to spontaneous eye opening and extubation were recorded. VAS-scale was used to assess postoperative pain. The incidence of nausea ＆ vomiting, agitation and respiratory depression was recorded and compared. Results Patients in group S had a more stable hemodynamic variables, and the incidence of postoperative pain（ VAS： group S 4. 2 ± 1.1, group C 6.1 ±1.2）, agitation （group S 2 cases, group C 11 cases） and respiratory depression （group S 1 case, group C 5 cases）was lower. Conclusions Both sufentanil and fentanyl were safe and efficacious in total intravenous anesthesia for liver resection. Compared with fentanyl, Sufentanil had higher hemodynamic stability, and lower incidence of postoperative pain, respiratory depression and agitation.

关 键 词：舒芬太尼/治疗应用 肝切除术 麻醉 静脉 血流动力学 

分 类 号：R614[医药卫生—麻醉学]