甘草药渣化学成分的分离与鉴定  

Chemical constituents from the residues of Glycyrrhiza inflata Batal.

作　　者：刘芬[1] 倪慧 卿德刚 孟大利[1] 李宁[1] 贾晓光 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 [2]新疆维吾尔自治区中药民族药研究所,新疆乌鲁木齐830002

出　　处：《中国药物化学杂志》2011年第4期312-314,共3页Chinese Journal of Medicinal Chemistry

基　　金：新疆维吾尔自治区科学技术厅资助项目(200915122)

摘　　要：目的对甘草药渣的化学成分进行研究,为甘草资源的再利用提供依据。方法利用硅胶、聚酰胺柱色谱及反复重结晶等方法进行分离纯化,根据理化性质及波谱分析对分离得到的化合物进行结构鉴定。结果分离得到9个已知化合物,分别鉴定为白桦酯酸(betulinic acid,1)、光甘草酮(glabrone,2)、甘草黄酮C(li-coflavone C,3)、甘草黄酮B(licoflavone B,4)、3-羰基甘草次酸(3-oxo-18β-g lycyrrhetinic acid,5)、芒柄花素(form onoetin,6)、甘草黄酮(licoflavone,7)、β-谷甾醇(β-sitosterol,8)、胡萝卜苷(daucostero l,9)。结论化合物1～6均为首次从甘草药渣中分离得到,化合物1、4、5为首次从胀果甘草中分离得到。For further application and development of the residues of Glycyrrhiza inflata Batal.,which was always deposited after production of glycyrrhizin on industrial,the bioactive constituents inside were studied.Nine compounds were isolated from the residues of Glycyrrhiza inflata Batal.by repeated chromatography on silica gel,Sephadex LH-20 column and polyamide column.Their structures were identified on the basis of physico-chemical constants and spectral analysis.Compounds 1-9 were identified as betulinic acid（1）,glabrone（2）,licoflavone C（3）,licoflavone B（4）,3-oxo-18β-glycyrrhetinic acid（5）,formonoetin（6）,licoflavone（7）,β-sitosterol（8） and daucosterol（9）.Compounds 1-6 were isolated from the residues of Glycyrrhiza inflata Batal.for the first time and compounds 1,4,5 were isolated from Glycyrrhiza inflata Batal.for the first time.

关 键 词：胀果甘草 甘草药渣 化学成分 鉴定 

分 类 号：R284[医药卫生—中药学]