过氧化物酶Ⅱ在心肌缺血／再灌注损伤中的保护作用  

Protective role of peroxiredoxin Ⅱ in ischemia/reperfusion injury of myocardium

作　　者：谢科宇[1] 杨天德[1] 

机构地区：[1]重庆市第三军医大学新桥医院麻醉科,400037

出　　处：《国际麻醉学与复苏杂志》2011年第4期494-496,共3页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金资助（30871061）;重庆市自然科学基金重点项目资助（CSTV2009BA5016）

摘　　要：背景过氧化物酶（peroxiredoxins，Prxs）在氧化应激反应中具有重要的保护作用。近年来研究发现，过氧化物酶Ⅱ（PrxⅡ）在心肌缺血，再灌注中变化显著，上调PrxⅡ表达对氧化应激损伤具有显著的保护作用，其作用机制有待澄清。目的总结PrxⅡ在氧化应激损伤中保护作用的调控机制，为改善缺血，再灌注损伤（ischemia／repeffusion injury，I／R1）的疗效提供新的思路。内容就PrxⅡ在心肌保护中的作用及研究进展做简要的综述。趋向PrxⅡ可能会成为氧化应激损伤中保护心脏的潜在靶点。Background Peroxiredoxins play crucial roles in protecting heart from oxidative stress-induced injury. Several lines of evidence suggest that expression level of peroxiredoxin Ⅱ （Prx Ⅱ ） was sharply changed in ischemia/repeffusion myoeardium and the overexpression of Prx Ⅱ significantly protected from H202-induced apoptosis and necrosis. And the underlying mechanisms were worth identifying. Objective To summarize the regulatory mechanisms on protective effec, t of Prx Ⅱ in oxidative stressinduced injury-may provide a promising way for cardiac protection from isehemia and reperfusion injury. Content To discuss the mechanisms underlying the protective role of Prx Ⅱ in oxidative stress -induced injury. Trend Prx Ⅱ may be a potential target for treating cardiac oxidative stress-induced injury.

关 键 词：过氧化物酶Ⅱ 过氧化氢 缺血/再灌注损伤 

分 类 号：R285.5[医药卫生—中药学]