乌鲁木齐市某区2005～2009年门诊抗痨化疗肺结核患者不良反应情况分析  

ANALYSIS OF THE ANTITUBERCULOSIS DRUG-INDUCED SIDE EFFECTS IN FREE PATIENTS WITH PULMONARY TUBERCULOSIS IN URUMQI SOME COUNTRY FROM 2005 TO 2009

作　　者：向阳[1] 优都斯.赛都拉 马金凤[1] 姚雪梅[1] 

机构地区：[1]新疆医科大学公共卫生学院流行病与卫生统计学教研室,乌鲁木齐830011

出　　处：《现代预防医学》2011年第15期3060-3064,共5页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(30960328)

摘　　要：[目的]了解乌鲁木齐市某区疾病预防控制中心结核病科门诊免费抗痨化疗肺结核患者不良反应发生情况,为预防和降低不良反应发生提供科学依据。[方法]回顾性分析2005年1月～2009年12月期间上报结核病管理信息系统资料,计算该人群不良反应发生率并分析其与性别、年龄、民族、职业、诊断分型、诊断结果、治疗分类、治疗方案等方面的关系。[结果]总不良反应发生率为10.8%,男、女不良反应发生率分别为10.9%和10.7%,青年组、中年组和老年组的不良反应发生率分别为7.6%、12.1%和21.5%,汉族、维吾尔族不良反应发生率分别为11.1%和10.3%。在不同职业中,不良反应发生率排在前3位的是:离退职人员(26.9%)、农民(16.7%)、家政、家务及待业(15.2%)。不良反应的主要影响因素为外地居民、青年组、粟粒患者,其调整的OR值及95%可信区间CI分别为0.536(0.296～0.969)、0.410(0.243～0.691)、2.932(1.262～6.810)。抗结核药物治疗过程中,用药后半月至1月者不良反应发生率最高为53.1%,其次为用药后1～2个月者(50.0%)。[结论]乌鲁木齐市某区抗结核药物引起的不良反应发生率较高。深入研究抗结核药物引起的不良反应,探索不良反应发生的危险因素,建立统一规范的不良反应识别、诊断标准以及临床治疗指南等,对预防和降低不良反应发生具有重要意义。[Objective]To investigate the antituberculosis drug-induced side effect in free patients with pulmonary tuberculosis,and therefore to provide scientific evidence for preventing and decreasing the incidence of adverse drug reactions.[Methods]Analysis was conducted retrospectively on calculating the overall incidence of adverse drug reactions and exploring the relationship between the gender,age,ethnic,occupation,diagnosis typing,diagnose results,therapy types and regimen,etc. respectively,which derived from the available data collected at the Center for Disease Prevention and Control in one district of Urumqi from January 2005 to December 2009.[Results]The total side effect rate was 10.8%. The side effect rate in male and female patients was 10.9% and 10.7% respectively,the difference was not significant. The side effect rate in the young age group,the middle age group and the old age group was 7.6%,12.1% and 21.5% respectively,the difference was significant. The side effect rate in Han and uygur patients was 11.1% and 10.3% respectively,the difference was not significant. Among the varied occupations,the order of the side effect rate was retiree（26.9%）,peasant（16.7%）,house or house-related work including unemployment（15.2%）. The major risk factors on the side effect rate were associated with not being native,the young,themiliary tuberculosis patients with adjusted OR and 95% CI as 0.536（0.296-0.969）,0.410（0.243-0.691）,2.932（1.262-6.810）respectively. During the antituberculosis drug treatment,the highest side effect rate（53.1%）occurred to the patients within 2 weeks to a month of exposure,the second（50.0%）within a month to 2 months of exposure.[Conclusion]The incidence of adverse reactions induced by antituberculosis drugs is high in one district of Urumqi.Therefore,studying on adverse reactions and the risk factors is helpful to prevent and reduce the incidence of adverse reactions through realizing the symptoms and establishing the diagnosis standards and clinical guides.

关 键 词：结核 肺 抗结核药物 不良反应 

分 类 号：R521[医药卫生—内科学]