上海市静安区2005～2008年分离到的志贺菌血清型分布及耐药性分析  

ANALYSIS ON SEROTYPE AND ANTIBIOTICS RESISTANCE OF SHIGELLA ISOLATED IN JINGAN DISTRICT OF SHANGHAI FROM 2005-2008

作　　者：李颐[1] 罗蓓[1] 胡雪明[1] 励庆[1] 赵文良[1] 

机构地区：[1]上海市静安区疾病预防控制中心检验科,上海200041

出　　处：《现代预防医学》2011年第15期3089-3090,3094,共3页Modern Preventive Medicine

摘　　要：[目的]分析2005～2008年静安区分离到的志贺菌菌型分布和耐药谱的变化,指导临床用药。[方法]参照《全国细菌性痢疾监测方案》(试行)对志贺菌进行鉴定及药敏试验,用WHONET5.4软件对药敏试验结果进行统计分析。[结果]共鉴定志贺菌139株,其中福氏志贺菌为67株,占48.20%;宋内志贺菌为72株,占51.80%。福氏志贺菌在2005年和2006年以F4c为主,而在2007年和2008年则逐渐转为以F2a为主。福氏志贺菌对利福平、奈啶酸、氨苄青霉素100%耐药,对四环素耐药率﹥90%。宋内志贺菌则对利福100%耐药,对奈啶酸、四环素、复方新诺明耐药率﹥90%。[结论]福氏和宋内志贺菌对第三代头孢菌素头孢噻肟耐药率已分别达到39.62%和27.45%,提示临床上应加强耐药性的监测,避免选择性压力和耐药基因的传播。[Objective]To investigate the changes of serotype and antibiotics susceptibility of Shigella in Jingan District from 2005-2008.[Methods]The project prescribed the uniform experimentation,quality control method,reagent,etc. Species collected in Jingan District were identified. Serotyping and the antibiotics susceptibility test were performed. Data were analyzed by WHONET 5.4 software.[Results]139 strains of Shigella in total,67 strains were S. flexneri,（48.20%）. and 72 strains were S. sonni（51.80%）. F4c were the major serotypes of S. flexneri in 2005-2006,while F2a were the major serotypes in 2007-2008. The resistant rate of S. flexneri to Rifampicin,Nalidixic Acid,Ampicillin were 100%,tetracycline was the second. The resistant rate of S. sonni to Rifampicin was 100%,nalidixic acid,tetracycline and compound sulfamethoxazole were over 90%.[Conclusion]In this locality,the resistant rate of S. flexneri and S.sonni to the third generation of cephalosporins are 39.62% and 27.45%,hence it is important to monitor the antimicrobial resistance to prevent the spread of genes of antibiotics resistance.

关 键 词：志贺菌 血清分型 药敏试验 多重耐药 

分 类 号：R378[医药卫生—病原生物学]