生长抑素联合丹参治疗乙型肝炎肝硬化合并急性胰腺炎的临床研究  

CLINICAL STUDY OF COMBINATION OF SANDOSTATIN WITH SALVIAE MILTIORRHIZAE(SM)IN TREATMENT OF HEPATITIS B CIRRHOSIS ASSOCIATED SEVERE ACUTE PANCREATITIS

作　　者：张国顺[1] 马利转 张超[1] 王玉兰[1] 徐晓平[1] 

机构地区：[1]河北省华北煤炭医学院附属医院消化内科,唐山063000

出　　处：《现代预防医学》2011年第15期3095-3096,3102,共3页Modern Preventive Medicine

基　　金：唐山市科技攻关指令项目(09130202A-3-6)

摘　　要：[目的]探讨生长抑素联合丹参对乙型肝炎肝硬化合并急性胰腺炎(AP)的治疗作用。[方法]乙型肝炎肝硬化合并急性胰腺炎患者105例,随机分为4组:对照组、生长抑素组、丹参组、联合组(生长抑素+丹参),分别从临床表现、实验室检查及预后等方面进行总结分析。[结果]与对照组比较,生长抑素组、丹参组及联合组,血淀粉酶、尿淀粉酶、ALT、AST、TBIL均明显下降(P﹤0.05);与对照组比较,生长抑素组、丹参组及联合组,乙型肝炎病毒标志物及HBV-DNA定量比较差异不具有统计学意义(P﹥0.05)。[结论]联合应用生长抑素和丹参治疗乙型肝炎肝硬化合并急性胰腺炎(AP)有协同作用,疗效优于单纯的西药治疗。[Objective]To investigate the therapeutic effects of combining somatostatin（SS）with salviae miltiorrhizae（SM）in curing Hepatitis B cirrhosis associated severe acute pancreatitis.[Methods]105 patients were randomly divided into four groups：control group,SS group,SM group and combination group. Changes of clinical symptoms,laboratory results and prognosis were observed.[Results]Compared with control group,hemodiastase,urinary amylase,ALT,AST and TBIL in SS,SM and combination group were significantly lower（P﹤0.05）;Compared with control group：virus markers of hepatitis and the content of HBV-DNA were not significant in other groups（P﹥0.05）.[Conclusion]The therapeutic effect of combining somatostatin with salviae miltiorrhizae in the treatment of Hepatitis B cirrhosis associated severe acute pancreatitis is superior to using western medicine alone.

关 键 词：肝硬化 胰腺炎 急性 生长抑素 丹参 中西医结合 

分 类 号：R969.4[医药卫生—药理学]