金黄益胆颗粒对原发性胆管结石患者术后血浆胃肠激素水平的影响  

Efficacy of jinhuangyidankeli to stomach-intestines hormone of primary bile duct stones patients

作　　者：劳万升[1] 曹立瀛[1] 刘四清[1] 付庆江[1] 

机构地区：[1]河北联合大学附属开滦医院肝胆外科,河北唐山063000

出　　处：《华北煤炭医学院学报》2011年第4期454-457,共4页Journal of North China Coal Medical College

摘　　要：①目的探讨金黄益胆颗粒临床作用机制。②方法采用放射免疫分析法(R IA)测定原发性胆管结石患者空腹外周静脉血浆胃动素(MOT)、生长抑素(SS)、血浆P物质(SP)的含量。比较服药组(金黄益胆颗粒组)、对照组(自然恢复组)、正常组(正常健康人)体内血浆胃肠激素水平。③结果正常组空腹血浆胃动素水平、P物质水平比胆管结石患者高,生长抑素水平比胆管结石患者低;服药组生长抑素达到正常组水平、SP接近正常组水平,均与对照组差异明显。④结论金黄益胆颗粒具有调节SS、SP的作用,预防胆色素结石的机制与此有关。Objective To evaluate the clinical therapeutic mechanism of Jinhuangyidankeli.Methods Motilin（MoT） Somatostatin（SS）and SP in the blood of the outside vein from the Primary Bile Duct StoneslimosisPatients were measured with radioimmunoassay.The levels of stomach-intestines hormone from the control group,recovering group and Jinhuangyidankeli group were compared.Results MTL and SP concentration in the blood of the outside vein from the primary bile duct stones patients decreased,but SS more increased than healthy human;somatostatin（SS）and SP concentration in the blood of the outside vein is awfully different in recovering group and Jinhuangyidankeli group.The somatostatin concentration in Jinhuangyidankeli group is considered arrived at the level of the control group and SP is closed to the control group.Conclusion Jinhuangyidankeli could increase the SP concentration and decrease the SS concentration in the primary bileduct stones patients,which might be related to prevention of pigment stones.

关 键 词：原发性胆管结石 胃动素 生长抑素 P物质 放射免疫检测法 

分 类 号：R283[医药卫生—中药学]