天荔汤对糖尿病大鼠早期肾脏高滤过的影响  

Effects of Tianli Decoction on Glomerular Hyperfiltration in Early Diabetic Rats

作　　者：陈国昌[1] 张灼[2] 彭海东[3] 欧阳忠兴[4] 

机构地区：[1]首都医科大学附属北京妇产医院,北京100026 [2]中国人民解放军第二炮兵总医院,北京100088 [3]中国人民解放军第二军医大学长征医院,上海200433 [4]湖北中医学院,湖北武汉430061

出　　处：《中国中医药信息杂志》2011年第8期30-32,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的观察天荔汤对糖尿病大鼠早期肾脏高滤过的影响。方法随机取8只大鼠作为正常组,余52只大鼠用四氧嘧啶诱导糖尿病大鼠模型,以血糖值在13～25 mmol/L者为成模,按血糖高低随机分为模型组、西药组和天荔汤高、低剂量组,每组8只,并给与相应药物。4周后检测大鼠血糖、肾质量、体质量、肾小球滤过率(GFR)及血浆一氧化氮(NO)、内皮素(ET)变化。结果与正常组相比,模型组血糖、尿量、肾质量、体质量、GFR、肾质量与体质量比值(KW/BW)等指标明显增高(P<0.01)。天荔汤高、低剂量组及西药组均能降低GFR,高剂量组与西药作用相当。天荔汤高剂量组能明显降低肾质量(P<0.01),并接近正常。天荔汤高剂量组KW/BW指数明显降低,优于天荔汤低剂量组与西药组(P<0.01)。结论天荔汤可明显改善糖尿病大鼠肾脏高滤过反应。Objective To observe the effect of Tianli Decoction on glomerular hyperfiltration in early diabetic rats kidney.Methods With 8 rats as normal group,52 rats were induced to diabetic model by alloxan.Thirty-two rats of blood glucose levels in 13-25 mmol/L were randomly divided into Tianli Decoction high dose group,Tianli Decoction low dose group,Captopril group,model group according to blood glucose level.Each group had 8 rats and was given corresponding drug.After 4 weeks,blood glucose,kidney hypertrophy,glomerular filtration rate（GFR） and plasma NO,ET were detected.Results Compared with normal group,the level of blood glucose,urinary protein and the ratio of kidney weight to body weight in model group were significantly increased.There was an elevation of the kidney/body weight（KW/BW） in early stage of the diabetes（P〈0.01）,and the GFR increased apparently（P〈0.01）.High and low dose of Tianli Decoction group and Captopril group all decreased GFR,the effect of the high dose group equalled to Captopril group.The high dose of Tianli Decoction group decreased kidney weight significantly（P〈0.01）,and close to normal.It also increased KW/BW,the effect was superior to the low dose group and Captopril group（P〈0.01）.Conclusion Tianli Decoction can obviously improve glomerular hyperfiltration in diabetic rats.

关 键 词：糖尿病肾病 天荔汤 肾小球滤过率 一氧化氮 内皮素 大鼠 

分 类 号：R289.11[医药卫生—方剂学]