血清胱抑素C测定在Ⅱ型糖尿病肾病早期诊断中的临床应用  

Clinical Value of Determination of Serum cystatin C in diabetic nephropathy

作　　者：周垚[1] 陆建荣[1] 陈琳[1] 吴月平[1] 

机构地区：[1]南通市第三人民医院检验科,江苏226006

出　　处：《交通医学》2011年第3期242-243,247,共3页Medical Journal of Communications

摘　　要：目的:探讨血清胱抑素C(Cys C)检测在糖尿病肾病早期临床诊断中的价值。方法:采用胶乳增强免疫比浊法测定糖尿病150例患者与健康对照组100例血清Cys C浓度比较,同时测定血尿素、肌酐。结果:(1)Cys C浓度:无DN组1.22±0.42 mg/L,对照组1.09±0.37 mg/L,两组比较差异无统计学意义(P>0.05);在糖尿病肾病组(DN)3组中,血清Cys-C浓度升高,Ⅲ期DN组2.00±0.32 mg/L,与无DN组比较(P<0.05)。Ⅳ期DN组>Ⅲ期DN组(P<0.01),V期DN组>Ⅳ期DN组(P<0.01)。(2)血清尿素和血清肌酐浓度,无DN组、Ⅲ期DN组分别与对照组比较差异无统计学意义(P>0.05),Ⅳ、Ⅴ期DN组血清尿素、血清肌酐浓度水平显著升高,差异有统计学意义(P<0.01)。结论:血Cys C检测对糖尿病肾病早期的临床诊断具有较大的实用价值。Objective： To investigate the clinical value of determination of serum cystatin C（Cys C） in diabetic nephropathy.Methods： Latex enhanced immunoturbidimetry was employed to analyze Cys C from 150 cases of diabetic patients and 100 healthy control group.And the values of serum urea and creatinine（CRE） were also detected.Results： The contents of serum Cys C suggested no difference between the patients free of nephropathy and the controls.The levels of Cys C were significantly higher in diabetic patients associated with nephropathy than in those of the controls（groupⅢ group free of nephropathy P〈0.05;groupⅣ groupⅢ P〈0.01;groupV groupⅣP〈0.01）.Although the levels of UREA and CRE were significantly higher in groupⅣ and group V than those in healthy Controls（P〈0.01）;there was not significantly difference between the patients free of nephropathy,groupⅢ and controls（P〉0.05）.Conclusion： The sensitivity and accuracy of the determination of serum Cys C in diabetic nephropathy are improved and might provide valuable proof for early diagnosis in diabetic nephropathy.

关 键 词：糖尿病肾病 胱抑素C 尿素 肌苷 胶乳增强免疫比浊法 

分 类 号：R587.2[医药卫生—内分泌]