白三烯B4在儿童幽门螺杆菌相关性胃炎发生中的作用  

Role of leukotriene B4 in serum and gastric juice in children with helicobacter pylori-associated gastritis

作　　者：林琼[1] 王叶红[1] 邹春燕[1] 唐国荣[1] 顾岚[1] 徐惠[1] 王辉[1] 莫会君[1] 

机构地区：[1]无锡市人民医院儿科,214023

出　　处：《江苏医药》2011年第15期1809-1810,共2页Jiangsu Medical Journal

摘　　要：目的探讨白三烯B4(LTB4)在儿童幽门螺杆菌(H.pylori)相关性胃炎发生中的作用。方法经胃镜确诊的胃炎45例患儿中,H.pylori阳性23例,H.pylori阴性22例。用ELISA法同时检测患儿血清及胃液中LTB4水平。结果 H.pylori阳性患儿血清LTB4为(2.063±1.016)ng/L,明显高于H.pylori阴性患儿的(0.441±0.894)ng/L(P<0.01);H.pylori阳性组胃液中LTB4浓度亦高于H.pylori阴性组(P<0.05)。结论 LTB4可能参与并促进H.pylori相关性胃炎发生、发展。Objective To investigate the role of leukotriene B4（LTB4） in the progress of children′s Helicobacter pylori（H.pylori）-associated gastritis（HPAG）.Methods The levels of LTB4 in serum and gastric juice were measured with ELISA in 45 children diagnosed as HPAG by gastroscope,of whom there were 23 cases with positive H.pylori and 22 cases negative.ResultsSerum LTB4 in H.pylori positive group was higher than that in H.pylori negative [（2.063±1.016）ng/L vs.（0.441±0.894）ng/L]（P〈0.01）.So did the level of LTB4 in gastric juice（P〈0.05）.Conclusion LTB4 may be involved in the occurrence and development of children′s HPAG.

关 键 词：白三烯B4 幽门螺杆菌相关性胃炎 儿童 

分 类 号：R725[医药卫生—儿科]