应用自我血糖监测评估糖化血红蛋白<6.5%的2型糖尿病患者的血糖波动  

Evaluation of blood glucose fluctuation by self-monitoring of blood glucose in type 2 diabetic patients with HbA1c<6.5%

作　　者：郭晓珍[1] 俞海燕[1] 施广德[1] 黄文龙[1] 

机构地区：[1]江阴市人民医院内分泌病科,214400

出　　处：《江苏医药》2011年第15期1818-1820,共3页Jiangsu Medical Journal

摘　　要：目的探讨自我血糖监测(SMBG)对了解糖化血红蛋白(HbA1c)<6.5%的2型糖尿病(T2DM)血糖波动的临床应用价值。方法对76例HbA1c<6.5%的T2DM患者进行SMBG,观察12周,分析其血糖变化。结果与监测前比较,76例患者的HbA1c均无明显变化。HbA1c与血糖日均值呈正相关,与血糖最低值、血糖最高值、最高血糖最低血糖差值、全天平均餐后最高血糖无关。在血糖监测值中(71.32±12.57)%的血糖值在目标血糖范围内,(10.72±4.39)%的血糖值出现过高现象,(6.21±2.85)%的血糖值为低血糖,同时还发现了无症状性低血糖。结论大多数HbA1c<6.5%的T2DM患者血糖实际控制并不理想,存在过高或过低的血糖;SMBG能较详细地了解T2DM患者血糖波动的特征,可为制定更为优化的降糖治疗方案提供临床依据。Objective To investigate the clinical value of self-monitoring of blood glucose （SMBG） in monitoring the fluctuation of blood glucose（BG） in type 2 diabetes mellitus （T2DM） patients with glycosylated hemoglobin lc （HbA1c）〈 6. 5%. Methods SMBG for continuous 12 weeks was performed in 76 T2DM patients with HbAlc〈6.5%. The fluctuation of 13（3 was analyzed. Results There was no significant difference in HbAlc between before and 12 weeks later in 76 T2DM patient（P〉0. 05）. The dayly HbAlc value was positively correlated to BG（P〈0. 01）, but was not associated with mean maximum BG, the subtraction value between maximum and minimum BG, mean minimum BG and mean postprandial maximum BG. SMBG showed that （71.32±12. 57）% BG values were in the target range, （10. 72± 4.39）% of BG values were excessively high, and （6.21 ±2. 85） of BG values were excessively low. Asymptomatic hypoglycemia was found in the study. Conclusion The apparent hyperglycemia and hypoglycemia exist in T2DM patients with HbAlc（6.5%. SMBG can offer much more information about the fluctuation in BG levels, which provides a reasonable choice for the treatment.

关 键 词：糖化血红蛋白 2型糖尿病 自我血糖监测 

分 类 号：R587[医药卫生—内分泌]