傅立叶轮廓术在重建三维物体轮廓中的应用  

Application of Fourier Transform Profilometry in 3D-surface Reconstruction

作　　者：石璧尔[1] 路宽 王颖婷[3] 李贞安[3] 白净[1] 

机构地区：[1]清华大学医学院生物医学工程系,北京100084 [2]生物医学工程研究生联合机构,伯克利大学CA94703 [3]新加坡国立大学工程学院生物工程系,新加坡117574

出　　处：《生物医学工程学杂志》2011年第4期649-652,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(81071191,60831003,30930092,30872633);清华-裕元基金,国家973计划项目资助(2011CB707701,2006CB705700);国家863计划项目资助(2006AA020803)

摘　　要：随着荧光分子断层成像(FMT)技术中系统结构和重建算法的改进,FMT技术已经成为一种重要的生命医学研究手段。目前FMT算法都需要得到被测对象的三维表面轮廓作为边界约束条件。本文提出一种在蓝紫光条件下基于傅立叶变换轮廓术(FTP)方法,经图像处理、频谱分析及滤波后重构出FMT系统实验中物体的轮廓。实验结果表明,该方法具有毫米量级的重建精度。该方法能够很好地重建出物体表面轮廓,以及实时监控实验过程中物体的行为,保证了整个成像过程的对应性。此外,该法选用蓝紫光段,避免了对荧光成像的干扰。With the improvement of system frame and reconstruction methods in fluorescent molecules tomography（FMT）,the FMT technology has been widely used as an important experimental tool in biomedical research.It is necessary to get the 3D-surface profile of the experimental object as the boundary constraints of FMT reconstruction algorithms.We proposed a new 3D-surface reconstruction method based on Fourier transform profilometry（FTP） method under the blue-purple light condition.The slice images were reconstructed using proper image processing methods,frequency spectrum analysis and filtering.The results of experiment showed that the method properly reconstructed the 3D-surface of objects and has the mm-level accuracy.Compared to other methods,this one is simple and fast.Besides its well-reconstructed,the proposed method could help monitor the behavior of the object during the experiment to ensure the correspondence of the imaging process.Furthermore,the method chooses blue-purple light section as its light source to avoid the interference towards fluorescence imaging.

关 键 词：荧光分子断层成像 傅立叶变换轮廓术 三维表面重建 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术]