血液介电参数与血液学指标的相关性分析  

The Correlation Analysis between Dielectric Parameters and Haematological Parameters in Whole Blood Cell

作　　者：陈晓敏[1] 丰明俊[1,2] 王力[1,2] 储慧民[1] 陈林[2] 马青[2] 

机构地区：[1]宁波市第一医院,宁波315010 [2]宁波大学医学院,宁波315211

出　　处：《生物医学工程学杂志》2011年第4期694-697,共4页Journal of Biomedical Engineering

基　　金：浙江省自然科学基金资助项目(Y207698);宁波市自然科学基金资助项目(2009A610176;2010A610074);宁波大学SRIP项目资助

摘　　要：利用4294A阻抗分析仪,在频率为0.01~100 MHz范围内测量了30例健康人血液样本的交流阻抗,同时测量了血沉（ESR）、红细胞比容（HCT）、血浆纤维蛋白原（FIB）及血糖（BG）等血液学指标,在获得完整数据的基础上,我们利用线性相关分析方法分析ESR与血液介电参数的相关性;并以多元回归统计学方法分析HCT、BG及FIB对全血细胞介电谱参数的影响。统计学结果显示ESR与部分血液介电参数呈线性相关;HCT和BG对部分血液介电参数有影响,其中HCT是影响血液介电参数最主要的血液学指标。We have measured the AC impedances of blood samples from 30 healthy adults with the Agilent 4294A impedance analyzer at frequency ranging 0.01-100MHz.At the same time,we measured the erythrocyte sedimentation rate（ESR）,hematocrit（HCT）,plasma fibrinogen（FIB）,blood glucose（BG） and D-dimer.Then we analyzed the correlation between ESR and dielectric parameters of blood by linear correlation analysis,and used multiple regression analysis to reveal the influence of these hematological data on dielectric spectral characteristics of whole blood cell when these data were available.Statistical analysis showed that ESR had a linear correlation with the part of dielectric parameters in whole blood cell.The Multiple linear regression analysis indicated that HCT and BG had an influence on dielectric spectral characteristics of human whole blood cell,and HCT was the major factor in haematological parameters that influenced dielectric spectral characteristics of whole blood cell.

关 键 词：血液细胞 介电特性 血沉 红细胞比容 血糖 多元回归分析 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]