血管组织工程支架的计算机辅助低温沉积制造研究  

Study on Computer-Aided Deposition Manufacturing of Vascular Tissue Engineering Scaffolds at Low Temperature

作　　者：李艳蕾[1] 徐铭恩[1] 王秋君[1] 袁梅娟[1] 胡金夫[1] 

机构地区：[1]杭州电子科技大学生物医学工程与仪器研究所,杭州310018

出　　处：《生物医学工程学杂志》2011年第4期804-809,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30600140;30970738;30800248;30400099);浙江省科技计划项目资助(2008C23077);浙江省自然科学基金资助项目(Y2091074)

摘　　要：实现血管支架的个性化制造,对于组织工程血管移植物(tissue-engineered vascular graft,TEVG)进入临床应用具有重要意义。本研究利用低温沉积制造(LDM)技术制造了管状支架及结构较复杂的血管网支架。并控制螺杆转速、扫描速度和喷头温度等工艺参数调控支架特性,对其表观特征进行了评测。所得支架能准确再现复杂的计算机辅助设计(CAD)的三维血管模型结构;支架壁厚随着螺杆转速与扫描速度之比的增加而增加;微孔尺寸、壁面平整度及支架壁厚与喷头温度成正相关,但是孔隙率受喷头温度影响不大。利用LDM技术可以制作出具有特定结构及表观特征的血管支架,对血管支架的个性化制造具有极大推动作用。Since there is a clinical need for the tissue-engineered vascular graft（TEVG）,fabricating the vascular scaffold individually appears to be necessary.In this work,we have developed the traditional tubular scaffold and branch vascular scaffold utilizing low-temperature deposition manufacturing（LDM） technology.Then different tubular scaffolds were fabricated by changing the processing parameters,and the morphological properties of the scaffolds were assessed.The scaffolds reproduced the structure of 3D vascular model accurately.Wall thickness of the scaffold increased with the increase of velocity ratio（VL/VS） and nozzle temperature,and both the micropore size and wall roughness were positively correlated with the nozzle temperature.However,the porosity was barely affected by the nozzle temperature.This approach,fabricating vascular scaffold with special structure and appearance features via LDM technology,is potential for the individual fabrication of vascular scaffold.

关 键 词：血管组织工程 支架 低温沉积制造 计算机辅助设计 表观特征 

分 类 号：R318.11[医药卫生—生物医学工程] R319[医药卫生—基础医学]