局限性硬皮病的UVA-1和PUVA治疗进展  

Advances in ultraviolet A1 phototherapy and psoralen plus ultraviolet A （PUVA） photochemotherapy for localized scleroderma

作　　者：朱晨雨[1] 孙秋宁[2] 

机构地区：[1]中国医学科学院北京协和医院内科,北京100730 [2]中国医学科学院北京协和医院皮肤性病科,北京100730

出　　处：《国际皮肤性病学杂志》2011年第4期222-224,共3页International Journal of Dermatology and Venereology

摘　　要：局限性硬皮病是一种结缔组织病,以局限性或弥漫性皮肤硬化或伴有内脏器官纤维化为特征,治疗方法包括物理治疗、药物治疗、紫外线和光化学疗法.其中紫外线和光化学疗法由于效果明显且不良反应小而成为近期研究的热点.大量临床及基础试验证明,紫外线可阻止纤维化进程,使硬化的皮肤斑块变软,尤其是UVA-1（340～400 nm）和光化学治疗PUVA更是取得了很好的效果.但是,目前的大多数试验在实验设计和效果评价方面尚没有统一的标准.Localized scleroderma （LS） is a connective tissue disease characterized by localized or diffused sclerosis of skin with or without the fibrosis of various internal organs.The management of LS includes physical treatment,drugs and phototherapy.Because of high efficiency and few side effects,phototherapy has become a hot spot of recent researches.Numerous clinical and basic researches have proved that phototherapy can block fibrosis progression,induce softening of already existing sclerotic lesions by suppressing inflammatory cell infiltration.In particular,long wave ultraviolet A1 （340-400 nm） and photochemotherapy （PUVA） have shown a satisfactory effect.However,no uniform standard is available for the design of trials and evaluation of efficacy.

关 键 词：硬皮病 局限性 紫外线 PUVA疗法 

分 类 号：R593.25[医药卫生—内科学]