大鼠纹状体边缘区P物质受体的免疫细胞化学研究  

Immunocytochemical localization of substance P receptor in the marginal division of rat striatum

作　　者：张魁华[1] 舒斯云[1] 朱利元[1] 

机构地区：[1]第一军医大学珠江医院全军神经医学中心,广州510282

出　　处：《解剖学研究》1999年第2期117-118,共2页Anatomy Research

摘　　要：目的 研究大鼠纹状体边缘区的结构与功能.方法 用免疫细胞化学技术对大鼠脑切片内P物质受体的定位分布进行研究.结果 P物质受体阳性胞体和树突在中枢神经系统有不均匀分布.纹状体边缘区内有较强P物质受体阳性胞体和树突,典型的梭形细胞沿背腹方向行走.结论 边缘区内有P物质受体的分布.推测边缘区内P物质递质有接受、整合功能.Objective To identify the precise targets of SP in the marginal division of rat striatum.Method The immuncytochemical method was used in the present study to systemically localize SP receptor(SPR)in the marginal division of rat striatum. Result SP-Like im-munoreactive products were found on the membrane of neuronal somata and dendrites.The positive reactive neurons were found non-uniformly in the central nervous system.There were strong positive neurons in the marginal division of rat striatum. These results suggest that the marginal di-vision cells of striatum contain SPR. Conclusion It conjectures that the marginal division may play the important functions included receiving and regulating the transmitter of SP.

关 键 词：P物质受体 纹状体边缘区 免疫细胞化学 大鼠 

分 类 号：R392.1[医药卫生—免疫学]