健脾止痒颗粒对脾虚血燥型特应性皮炎患者Th1/Th2细胞因子谱的影响  

Influence of "Jianpi Zhiyang Granule" on Thl/Th2 Cytokines in Patients with Atopic Dermatitis of Spleen-deficiency and Blood-dryness Syndrome

作　　者：金培志[1] 杨瑛[1] 赵跃凤[1] 郭岱炯[1] 

机构地区：[1]广东省深圳市中医院皮肤科,广东深圳518033

出　　处：《上海中医药大学学报》2011年第4期60-62,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：广东省深圳市科技计划项目(200902135)

摘　　要：目的:探讨健脾止痒颗粒对特应性皮炎(AD)患者Th1/Th2细胞因子谱的影响。方法:将60例特应性皮炎患者随机分为治疗组(30例)和对照组(30例),分别服用健脾止痒颗粒和氯雷他定片,疗程1个月。另设正常组(20例健康志愿者)作对照观察。采用Flowcytomix流式检测技术对各组血清Th1/Th2相关细胞因子进行芯片式集成测定。结果:与正常组比较,治疗前两组AD患者粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平显著降低(P<0.05);Th1型细胞因子IL-1α、IL-2、IFN-γ、TNF-α水平显著降低(P<0.05);Th2型细胞因子IL-4、IL-5、IL-6、IL-10水平显著升高(P<0.05)。治疗后两组GM-CSF、IL-1α、IL-2、TNF-α、IFN-γ水平较治疗前明显升高(P<0.05),且治疗组IFN-γ水平升高更显著(P<0.05);两组IL-4、IL-5、IL-6、IL-10水平较治疗前明显降低(P<0.05),且治疗组IL-4水平降低更显著(P<0.05)。结论:健脾止痒颗粒可通过调节Th1/Th2细胞因子网络的平衡发挥对AD的免疫治疗作用。Objective： To study the influence of ＂Jianpi Zhiyang Granule＂,a herbal formula,on Thl/Th2 cytokines in patients with atopic dermatitis（AD）.Methods： Sixty patients with AD of spleen-deficiency and blood-dryness syndrome were randomized into two groups： treatment group in which 30 cases were treated with ＂Jianpi Zhiyang Granule＂ and control group in which 30 cases were treated with loratadine tablet,with a course of one month.Besides 20 healthy persons were enrolled as control.The serum Th1/Th2 cytokines were determined by Flowcytomix technology.Results： Compared with healthy people,the level of serum GM-CSF in AD patients were significantly decreased（P0.05）;the levels of such Th1 cytokines as IL-1α,IL-2,IFN-γ and TNF-α were markedly declined（P0.05）;while the contents of such Th2 cytokines as IL-4,IL-5,IL-6 and IL-10 were significantly increased（P0.05）.After treatment,the levels of GM-CSF,IL-1α,IL-2,TNF-α and IFN-γ were increased in the two groups（P0.05）,with higher level of IFN-γ in treatment group than in control group（P0.05）;the contents of IL-4,IL-5,IL-6 and IL-10 were remarkably decreased in the two groups（P0.05）,with more significant decrease in the content of IL-4 in treatment group than in control group（P0.05）.Conclusion： ＂Jianpi Zhiyang Granule＂ can balance the Thl/Th2 cytokines to treat atopic dermatitis.

关 键 词：特应性皮炎 细胞因子 健脾止痒颗粒 

分 类 号：R275.9[医药卫生—中西医结合] R753.9[医药卫生—中医皮科]