健脾止痒颗粒对脾虚血燥型特应性皮炎患者Th1/Th2细胞因子谱的影响  被引量:6

Influence of "Jianpi Zhiyang Granule" on Thl/Th2 Cytokines in Patients with Atopic Dermatitis of Spleen-deficiency and Blood-dryness Syndrome

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作  者:金培志[1] 杨瑛[1] 赵跃凤[1] 郭岱炯[1] 

机构地区:[1]广东省深圳市中医院皮肤科,广东深圳518033

出  处:《上海中医药大学学报》2011年第4期60-62,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基  金:广东省深圳市科技计划项目(200902135)

摘  要:目的:探讨健脾止痒颗粒对特应性皮炎(AD)患者Th1/Th2细胞因子谱的影响。方法:将60例特应性皮炎患者随机分为治疗组(30例)和对照组(30例),分别服用健脾止痒颗粒和氯雷他定片,疗程1个月。另设正常组(20例健康志愿者)作对照观察。采用Flowcytomix流式检测技术对各组血清Th1/Th2相关细胞因子进行芯片式集成测定。结果:与正常组比较,治疗前两组AD患者粒细胞-巨噬细胞集落刺激因子(GM-CSF)水平显著降低(P<0.05);Th1型细胞因子IL-1α、IL-2、IFN-γ、TNF-α水平显著降低(P<0.05);Th2型细胞因子IL-4、IL-5、IL-6、IL-10水平显著升高(P<0.05)。治疗后两组GM-CSF、IL-1α、IL-2、TNF-α、IFN-γ水平较治疗前明显升高(P<0.05),且治疗组IFN-γ水平升高更显著(P<0.05);两组IL-4、IL-5、IL-6、IL-10水平较治疗前明显降低(P<0.05),且治疗组IL-4水平降低更显著(P<0.05)。结论:健脾止痒颗粒可通过调节Th1/Th2细胞因子网络的平衡发挥对AD的免疫治疗作用。Objective: To study the influence of "Jianpi Zhiyang Granule",a herbal formula,on Thl/Th2 cytokines in patients with atopic dermatitis(AD).Methods: Sixty patients with AD of spleen-deficiency and blood-dryness syndrome were randomized into two groups: treatment group in which 30 cases were treated with "Jianpi Zhiyang Granule" and control group in which 30 cases were treated with loratadine tablet,with a course of one month.Besides 20 healthy persons were enrolled as control.The serum Th1/Th2 cytokines were determined by Flowcytomix technology.Results: Compared with healthy people,the level of serum GM-CSF in AD patients were significantly decreased(P0.05);the levels of such Th1 cytokines as IL-1α,IL-2,IFN-γ and TNF-α were markedly declined(P0.05);while the contents of such Th2 cytokines as IL-4,IL-5,IL-6 and IL-10 were significantly increased(P0.05).After treatment,the levels of GM-CSF,IL-1α,IL-2,TNF-α and IFN-γ were increased in the two groups(P0.05),with higher level of IFN-γ in treatment group than in control group(P0.05);the contents of IL-4,IL-5,IL-6 and IL-10 were remarkably decreased in the two groups(P0.05),with more significant decrease in the content of IL-4 in treatment group than in control group(P0.05).Conclusion: "Jianpi Zhiyang Granule" can balance the Thl/Th2 cytokines to treat atopic dermatitis.

关 键 词:特应性皮炎 细胞因子 健脾止痒颗粒 

分 类 号:R275.9[医药卫生—中西医结合] R753.9[医药卫生—中医皮科]

 

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