益气健脾中药对二甲基肼诱导大肠肿瘤小鼠的干预效应  

Effects of Qi-nourishing and Spleen-strengthening Herbs on Colorectal Neoplasms Induced by Dimethylhydrazine in Mice

作　　者：赵凡尘[1] 殷晓聆[1] 

机构地区：[1]上海中医药大学附属市中医医院肿瘤科,上海200071

出　　处：《上海中医药大学学报》2011年第4期63-65,F0003,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市中医肿瘤临床优势专科基金项目(2008YSKZK008)

摘　　要：目的:观察益气健脾中药对二甲基肼诱导的大肠肿瘤小鼠模型在抑制肿瘤生成方面的作用。方法:将80只小鼠随机分为模型对照组及益气健脾中药高、中、低剂量组,以二甲基肼诱导小鼠大肠肿瘤模型,药物干预组予以灌胃益气健脾汤。计算、检测各组小鼠荷瘤数、体质量及血红蛋白含量。结果:高剂量组小鼠的平均荷瘤数、癌结节发生率及肠癌发生率低于模型对照组(P<0.05);高剂量组小鼠的血红蛋白含量高于中剂量组(P<0.05)及模型对照组(P>0.05);各组之间体质量无差异(P>0.05)。结论:早期运用益气健脾汤能够抑制二甲基肼诱导的小鼠大肠肿瘤的发生,并提高小鼠的机体功能。Objective：To observe the effects of qi-nourishing and spleen-strengthening herbs on colorectal neoplasms induced by 1,2-dimethylhydrazine（DMH） in mice.Methods： Eighty mice were randomly divided into model group,and high-,middle-and low-dose qi-nourishing and spleen-strengthening herbs groups.The colorectal neoplasms models in mice were induced by DMH,and all the qi-nourishing and spleen-strengthening herbs groups were intragastrically administered by qi-nourishing and spleen-strengthening decoction.The tumor-bearing amount,weight and hemoglobin were observed.Results： The average number of tumor,incidence of cancer nodules and incidence of colorectal cancer in high-dose group were lower than those in model group（P0.05）;the level of hemoglobin in high-dose group was higher than that in middle-dose group and model group（P0.05）;there was no significant difference in weights between different groups（P0.05）.Conclusion： Early application of qi-nourishing and spleen-strengthening herbs can prevent the colorectal cancer in mice induced by DMH,and improve the immune function of mice.

关 键 词：益气健脾法 肠肿瘤 二甲基肼 

分 类 号：R285.5[医药卫生—中药学] R735.3[医药卫生—中医学]