益气增敏方对2型糖尿病大鼠早期肾病的防治作用  

Effects of "Yiqi Zengmin Recipe" on Early Type 2 Diabetic Nephropathy in Rats

作　　者：薛红丽[1] 张曾[1] 王文健[1] 陈伟华[1] 应健[1] 

机构地区：[1]复旦大学附属华山医院中医科,上海200040

出　　处：《上海中医药大学学报》2011年第4期71-73,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：霍英东教育基金会高校青年教师优选资助项目(114036)

摘　　要：目的:探讨益气增敏方对2型糖尿病大鼠早期肾病的防治作用。方法:采用高脂饮食联合链脲佐菌素建立稳定的2型糖尿病大鼠早期肾病模型,随机分为模型组、益气增敏方治疗组、氯沙坦对照组、罗格列酮对照组。连续灌胃给药8周,观察治疗前后血糖、血脂、HOMA-IR、尿微量白蛋白(MAU)的变化。结果:益气增敏方可降低糖尿病肾病大鼠的MAU水平,有效改善胰岛素抵抗,降低TG、TC、LDL-c,升高HDL-c水平,还有降低血糖的作用,其疗效优于氯沙坦及罗格列酮。结论:益气增敏方可有效防治2型糖尿病早期肾病,其作用机制与改善糖脂代谢紊乱及胰岛素抵抗有关。Objective： To explore the effects of ＂Yiqi Zengmin Recipe＂ on early type 2 diabetic nephropathy in rats.Methods： The early type 2 diabetic nephropathy rats were induced by the high-fat diets combined with streptozotocin（STZ）,and were randomly divided into four groups： model group,＂Yiqi Zengmin Recipe＂ group,losartan group and rosiglitazone group.After continuous stomach perfusion administration for 8 weeks,the changes of blood glucose,blood lipid,HOMA-IR and MAU were observed.Results： ＂Yiqi Zengmin Recipe＂ could decrease the levels of MAU,TG,TC LDL-c and blood glucose,increase the level of HDL-c,and improve the insulin resistance.These effects above of ＂Yiqi Zengmin Recipe＂group were better than those of losartan and rosiglitazone groups.Conclusion： ＂Yiqi Zengmin Recipe＂ can prevent and treat the early type 2 diabetic nephropathy in rats,and its mechanisms may have relationship with improving the disorder metabolism of glucolipid and insulin resistance.

关 键 词：益气增敏方 糖尿病肾病 胰岛素抵抗 血脂 尿微量白蛋白 

分 类 号：R285.5[医药卫生—中药学] R587.1[医药卫生—中医学]