血管内皮生长因子在妊娠期肝内胆汁淤积症中的表达及其意义  

Expression and significance of vascular endothelial growth factor in patients with intrahepatic cholestasis of pregnancy

作　　者：陈忠[1] 张婷[1] 许建娟[1] 许飞[1] 冯一中[2] 

机构地区：[1]江苏省无锡市妇幼保健院,214002 [2]苏州大学医学院,江苏苏州215006

出　　处：《中国妇幼保健》2011年第22期3464-3465,共2页Maternal and Child Health Care of China

基　　金：江苏省无锡市科技发展计划项目〔CSE00911〕

摘　　要：目的:探讨血管内皮生长因子(VEGF)与妊娠肝内胆汁淤积症(ICP)发病的关系。方法:采用酶联免疫吸附试验(ELISA)检测30例ICP孕妇(观察组)和30例正常孕妇(对照组)静脉血清、羊水和脐静脉血清VEGF的表达水平。结果:观察组孕妇静脉血清、羊水和脐静脉血清VEGF的表达水平与对照组相比明显降低,差异有统计学意义(P<0.01)。结论:VEGF表达水平的显著下降可能是ICP发病机制中的一个重要因素。Objective：To explore the relationship between vascular endothelial growth factor（VEGF） and pathogenesis of intrahepatic cholestasis of pregnancy（ICP）.Methods：The expression levels of VEGF in venous serum,amniotic fluid and umbilical venous serum of 30 pregnant women with ICP（observation group） and 30 normal pregnant women（control group） were detected by ELISA.Results：The expression levels of VEGF in venous serum,amniotic fluid and umbilical venous serum in observation group were significantly lower than those in control group（P0.01）.Conclusion：The significant decrease of expression level of VEGF may play an important role in the pathogenic mechanism of ICP.

关 键 词：血管内皮生长因子 妊娠肝内胆汁淤积症 酶联免疫吸附试验 

分 类 号：R714.25[医药卫生—妇产科学]