条件刺激与不同浓度的抗原激发哮喘发作结合的实验研究  

The experimental study on the combiation effects of CS and antigen in different concentrations on provokme asthma

作　　者：张晓奇 郑红淑 张忠芳 

机构地区：[1]吉林医学院附属医院神经内科 [2]吉林医学院药理教研室 [3]吉林医学院医学病生教研室

出　　处：《吉林医学院学报》1999年第2期4-7,共4页

摘　　要：目的：观察条件刺激与免疫性非条件刺激结合对免疫学效应的影响。方法：采用经典的声不 条件刺激，以５０％ＡＯ，２．５％ＯＡ，１％ＯＡ抗原激发豚鼠引发支气管哮喘作为非条件刺激，对照组不予以声光刺激，经过五周的结合训练，观察各组的哮喘情况。结果：条件刺激组３组各周的哮喘发作阳性程度无差异，非条件刺激组与第１周差异不明显，但从第３周到老５周有明显的差异，与条件刺激组相比出现不同的程度的耐受。Objective:To observe the combination effects of CS and immunological non-CS on immunizing effect.Methods:Classical audio-visual design was used as conditioned stimulus.5%,2.5% and 1% of OA antigen were used as non-conditioned stimulus to provoke bronchial asthma in guinea pig.No audiovisual stimulus was used in controlling group.The attacks of asthma in each group were observed after five week general training.Result:There were no significant differences between the positive asthma attacks in the three CS groups in each week.In the first week the differences between CS groups and no-CS groups were not prominent,but from the third week to the fifth week the differences became significant comparing CS groups, different degrees of immunotolerance occurred and the sensitivity of asthma attack was decreased.Conclusion:The presence of CS can change the immunizing effect with the presence of immunological non-CS and this will found the basis for the establishment of conditioned immnoreaction asthma mode.

关 键 词：条件刺激 不同抗原浓度 激发哮喘 哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]