长期应用小剂量氨茶碱对稳定期慢性阻塞性肺疾病患者、动物外周血、骨髓粒细胞增殖的影响  

The effect of long-term use of low-dose aminophylline on stable chronic obstructive pulmonary disease,animal blood,bone marrow granulocyte proliferation

作　　者：王玲玲[1] 张旭华[1] 刘朔[1] 何小宇[1] 聂芳[1] 张丽娇[1] 马列[1] 王群[1] 赵明静[1] 闻德亮[1] 王笑歌[1] 

机构地区：[1]中国医科大学附属第四医院,辽宁沈阳110032

出　　处：《中国医学工程》2011年第6期1-3,6,共4页China Medical Engineering

基　　金：国家科技支撑计划课题(2007BAI24B04);中华医学会基金项目(07010250033);(070103200400);(08020680146)

摘　　要：目的探讨长期应用小剂量氨茶碱(Aminophyllin,AP)对稳定期慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)患者、动物骨髓、外周血粒细胞增殖的影响。方法 (1)应用前瞻、随机分组、对照及自身对照的方法,将1252例稳定期COPD患者(Ⅱ～Ⅲ级)分为治疗组(常规治疗+茶碱缓释片0.4g/d)和对照组(常规治疗)。治疗开始后每间隔15d复查1次血常规,对治疗前后的指标进行自身前后比较。(2)25只实验用羊采用自身对照法,在应用AP 3mg/(kg.d)后,对治疗前后的各项指标进行自身前后比较。结果 (1)长期应用小剂量AP,对稳定期COPD患者的外周血粒细胞增殖无影响(P>0.05);(2)长期应用小剂量AP可使动物的骨髓嗜酸性粒细胞增生活跃(P<0.05);(3)长期应用小剂量AP对动物的骨髓、外周血粒细胞增生无影响(P<0.05)。结论长期应用小剂量AP可使骨髓嗜酸性粒细胞增生活跃以提高机体抗炎及调节免疫能力,而对骨髓血红系统及外周血粒细胞增殖无影响。【Objective】 To explore the effect of long-term use of low-dose aminophylline on stable patients with chronic obstructive pulmonary disease、animal bone marrow、peripheral blood granulocyte proliferation.【Methods】（1）Using prospective studies、random allocation、controlled and self-control methods,we divided 1500 stable COPD patients（GradeⅡ-Ⅲ） into treatment group（Conventional therapy＋Oral theophylline0.4g/day） and control group（Conventional therapy）.Group and self comparisons were made for indications before and after treatment.（2）Using self-control method,indications of 25 experimental sheep with AP[3mg mg/（kg·d）]in treatment were compared before and after.【Results】（1）There was no effect of long-term use of low-dose AP on granulocytes proliferation in peripheral blood of patients with stable COPD（P 0.05）.（2）The long-term use of low-dose AP could stimulate the eosinophils proliferation in bone marrow of animals（P 0.05）.（3） There was no influnce on granulocytes proliferation in peripheral blood and bone marrow of animals after long-term application of low-dose AP（P 0.05）.【Conclusion】 The long-term use of low dose AP causes active eosinophilic granulocyte proliferation in bone marrow so as to promote the ability of anti-inflammatory and immunoregulation,but there is no effect on the proliferation of granulocytes in peripheral blood.

关 键 词：氨茶碱 慢性阻塞性肺疾病 外周血/骨髓 调节免疫 人/动物 

分 类 号：R563[医药卫生—呼吸系统]