首乌延寿丹对家兔骨关节炎的防治作用及其可能机制  

The preventive effect of SWYSD on the osteoarthritis in rabbits animal model and its possible mechanism

作　　者：张威[1] 王桂敏[2] 

机构地区：[1]辽宁医学院研究生学院,辽宁锦州121000 [2]辽宁医学院附属第一医院,辽宁锦州121000

出　　处：《中国医学工程》2011年第6期52-53,共2页China Medical Engineering

摘　　要：目的观察首乌延寿丹对兔骨关节炎(Osteoarthritis,OA)的防治作用。方法将24只日本大耳白兔随机分成空白对照组、模型组、首乌延寿丹组。ACLT术[1]制作OA模型。于第12周末观察软骨病理形态学改变;免疫组化法测定软骨Ⅱ型胶原及基质金属蛋白酶-1(MMP-1)的表达。结果以ACLT术成功建立了OA模型。首乌延寿丹组病变明显减轻,Ⅱ型胶原的蛋白表达明显升高(P<0.01);MMP-1表达明显降低(P<0.01)。结论首乌延寿丹可明显抑制OA发展,这一作用可能是通过增加Ⅱ型胶原的蛋白表达、下调MMP-1表达来实现的。【Objective】 To investigate the preventive effects of SWYSD on the rabbits with Osteoarthritis（OA）.【Methods】 24 Japan big-ear white rabbits were randomly divided into normal control group﹑model group﹑SWYSD group.The OA model was established with ACLT.Pathological changes of collagen was observed and the expression of typeⅡcollagen and metalloproteinase-1（MMP-1） was detected by immunohistochemistry in the 12th week.【Results】 The OA model was successfully established with ACLT.There was severe pathological lesion in model group;The expression of typeⅡcollagen in model group were upwnregulated（P0.01）,the expression of MMP-1 in model group were downregulated（P0.01）.【Conclusion】 SWYSD can prevent the formation of OA by upregulating the expression of typeⅡcollagen and downregulating the expression of MMP-1.

关 键 词：首乌延寿丹 骨关节炎 Ⅱ型胶原 基质金属蛋白酶-1 

分 类 号：R684.3[医药卫生—骨科学]