慢性肾脏病基础上出现急性肾损伤相关因素的临床分析  

Clinical analysis of risk factors of acute kidney injury in patients with chronic kidney disease

作　　者：袁利[1] 徐贵华[1] 李雁[1] 谢平[1] 陈永华[1] 赵晋媛[1] 黄艳玲[1] 郭洁[1] 曹凯[1] 

机构地区：[1]上海市第八人民医院肾内科,200235

出　　处：《中国医师进修杂志》2011年第22期16-18,共3页Chinese Journal of Postgraduates of Medicine

基　　金：基金项目：上海市第六人民医院联合体课题

摘　　要：目的探讨慢性肾脏病（CKD）基础上出现急性肾损伤（AKI）的相关危险因素，为早期干预、延缓CKD进程提供依据。方法将127例CKD患者根据有无合并AKl分组，未合并AKI者60例（CKD组），合并AKI者67例（A／C组），再将A／C组患者按年龄分组，其中〈60岁35例（非老年组），≥160岁32例（老年组）。就其原发病、诱发因素等进行分析。结果不同年龄组CKD患者诱发AKI的病因有不同特点；CKD基础上出现AKI相关危险因素如严重感染、血容量不足、心力衰竭、使用肾毒性药物的OR值分别为5．236、5．083、8．283、5．246，P〈0．05。结论CKD患者易受多种因素影响，重视CKD基础上出现AKI的高危因素并及早发现，争取在短时间内纠正危险因素和保护肾功能，对延缓CKD的进程和改善患者的预后有重要意义。Objective To evaluate the risk factors of patients with acute kidney injury （AKI） in patients with chronic kidney disease （CKD） for the early detection and early treatment of CKD. Methods One hundred and twenty-seven CKD patients were divided into groups according to AKI existing, 60 cases with out AKI （CKD group）, 67 cases with AKI （A/C group） and then A/C group patients were divided into non-older age group （35 cases, 〈 60 years old） and older age group （32 cases, ≥60 years old）. The protopathy, causative factors and so on were analyzed. Results There was different causative factors in different age group. Logistic regression model indicated that the major risk flaetors of AKI in CKD were severe infection （OR = 5.236）,hypovolemia （OR = 5.083 ）,heart failure （OR = 8.283） and using renal toxicity medicine （OR = 5.246）,P 〈 0.05. Conclusion The major risk factors of AKI in CKD patients include severe infection, hypovolemia, heart failure and renal toxicity medicine.

关 键 词：肾病 危险因素 急性肾损伤 

分 类 号：R692[医药卫生—泌尿科学]