超敏C反应蛋白与高血压危险因素和靶器官损害的相关性研究  

Correlation study of high-sensitivity C-reactive protein with risk factors and target organ damage in hypertensive patients

作　　者：丁彦春[1] 王健[2] 张鹏强[1] 曲鹏[1] 

机构地区：[1]大连医科大学附属第二医院心血管内科,116027 [2]天津市第四中心医院CCU

出　　处：《中国医师进修杂志》2011年第22期22-25,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨超敏C反应蛋白（hs-CRP）与原发性高血压危险因素及不同靶器官损害的关系。方法测定216例原发性高血压患者（高血压组）和36例同期健康志愿者或因胸痛、胸闷，疑诊心脏神经官能症人院检查的患者（对照组）血清hs—CRP水平，比较原发性高血压合并不同疾病、受累靶器官的多少及不同受累靶器官之间血清hs．CRP水平的差异，并分析各变量与血清hs-CRP水平的相关性。结果高血压组血清hs—CRP水平显著高于对照组[（1．99±0．34）mg／L比（1．10±0．26）mg／L]（P〈0．01）。高血压合并冠心病者与高血压合并糖尿病者血清hs．CRP水平[分别为（2．39±0．24）、（2．104-0．18）mg／L]显著高于单纯高血压者[（1．85±0.30）mg／L]，高血压合并冠心病者血清hs—CRP水平高于高血压合并糖尿病者，差异有统计学意义（P〈0．05）。血清hs—CRP水平与靶器官损害数目呈正相关（r=0．747，P〈0．01）。高血压合并不同靶器官损害者血清hs—CRP水平有差异，其中高血压合并左室肥厚者血清hs-CRP水平显著高于高血压合并颈动脉粥样硬化、。肾损害及眼底病变者，差异有统计学意义（P〈0．05）。高血压合并颈动脉粥样硬化者血清hs-CRP水平与高血压合并肾损害者比较差异无统计学意义（P〉0．05）。逐步回归分析显示，影响血清hs—CRP水平的主要因素为左室质量指数（LVMI）、年龄和高密度脂蛋白胆固醇（HDL-C），其中与HDL—C呈负相关。结论原发性高血压患者血清hs-CRP水平明显高于正常人群，高血压合并不同疾病时炎性反应程度不同，高血压合并冠心病患者的hs-CRP水平显著高于高血压合并糖尿病患者。血清hs-CRP水平与靶器官损害数目呈正相关；靶器官损害不同，炎性反应程度不同。影响hs—CRP水平的主要因素为LVMI、年龄和HDL—C，其中与HDL—C呈负相关。Objective To explore the correlation of high-sensitivity C-reactive protein （hs-CRP） with risk factors and target organ damage in hypertensive patients. Methods The levels of serum hs-CRP of 216 hypertensive cases （hypertension group） and 36 healthy subjects （control group） were tested and compared among different associated diseases, the number of involved target organ and the difference of involved target organ. The relativity between variables such as total cholesterol, high density lipoprotein cholesterol （HDL-C）, left ventricular mass index （LVMI） and so on and hs-CRP was analyzed by linear correlation analysis and multiple linear regression analysis. Results The levels of serum hs-CRP in hypertension group were higher than those in control group [ （ 1.99 ± 0.34） mg/L vs. （ 1.10± 0.26） mg/L] （P 〈 0.01 ）. The levels of serum hs-CRP in hypertension combined with coronary disease and hypertension combined with diabetes mellitus [ （2.39 ± 0.24）, （2.10± 0.18） mg/L, respectively] were higher than those in simple hypertension[ （1.85 ±0.30） mg/L ], and the levels of serum hs-CRP in hypertension combined with coronary disease were higher than those in hypertension combined with diabetes mellitus, and there were significant difference （P 〈 0.05 ）. The levels of serum hs-CRP were positively correlated with the number of involved target organ （r = 0.747,P 〈 0.01 ）. There were significant differences among different associated diseases. The levels of serum hs-CRP in hypertension combined with left ventricle thickening were higher than those in hypertension combined with carotid atherosclerosis, renal damage and diabetic retinopathy, and there were significant differences （P 〈 0.05 ）. There was no significant difference in the level of serum hs-CRP between hypertension combined with carotid atherosclerosis and hypertension combined with renal damage （P 〉 0.05）. Stepwise regression analysis showed that the dominating factors of the level of serum hs

关 键 词：C反应蛋白质 高血压 靶器官损害 

分 类 号：R544.1[医药卫生—心血管疾病]