高分辨磁共振成像用于阿尔茨海默病嗅球体积测量  

Application of High-resolution Magnetic Resonance Imaging in Measuring Olfactory Bulb Volume in Patients with Alzheimer Disease

作　　者：有慧[1] 牛富生[2] 王剑[3] 郑福玲[1] 孟春玲[1] 张振馨[2] 倪道凤[3] 冯逢[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院神经内科,北京100730 [3]中国医学科学院北京协和医学院北京协和医院耳鼻喉科,北京100730

出　　处：《协和医学杂志》2011年第3期209-212,共4页Medical Journal of Peking Union Medical College Hospital

摘　　要：目的评价阿尔茨海默病(Alzheimer disease,AD)患者嗅球体积变化。方法对14例AD患者及25名正常老年志愿者行高分辨嗅球磁共振成像(magnetic resonance imaging,MRI),测量嗅球体积。结果 AD患者较大侧嗅球体积为(32·2±7·7)mm3,小于正常老年志愿者的(40·6±6·6)mm3(P=0·002)。AD患者嗅球体积与简易精神状态检查量表(mini-mental state examination,MMSE)评分无明显相关性(P=0·205)。结论 AD患者嗅球体积减小,符合神经病理学表现。MRI可以发现AD患者嗅球体积改变,可能为AD诊断提供帮助。Objective To explore the change of olfactory bulb （OB） volume in patients with Alzheimer disease （AD） and assess the value of high-resolution magnetic resonance imaging （MRI） in measuring OB volume. Methods Fourteen AD patients and 25 normal aging volunteers （control group） underwent high-resolution MRI imaging of OB and the OB volume was measured. Results The OB volume in AD patients [ （32.2±7.7） mm3] was significantly smaller than that in control group [（40.6±6.6） mm3] （P=0.002）. The OB volume in AD patients didn＇t correlate significantly with their mini-mental state examination （MMSE） scores （P=0.205）. Conclusions AD patients show more prominent OB atrophy than normal aging volunteers do, which is in agreement with the pathological findings. High-resolution MRI is valuable in identifying the change of OB volume and therefore might be beneficial for AD diagnosis.

关 键 词：阿尔茨海默病 磁共振成像 嗅球 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.16[医药卫生—诊断学]