有氧运动与平肥方对DIO大鼠脂代谢和胰岛素抵抗的影响  

Effect of aerobic exercise and Pingfeifang on lipid metabolism and insulin resistant of DIO rats

作　　者：申忠华[1] 何军锋[1] 罗华[1] 

机构地区：[1]湖南中医药大学,湖南长沙410007

出　　处：《湖南中医药大学学报》2011年第8期3-5,共3页Journal of Hunan University of Chinese Medicine

基　　金：中医诊断学重点学科;中医病证重点实验室建设项目资助

摘　　要：目的评价有氧运动与平肥方对高脂饮食所致肥胖大鼠(DIO)脂肪代谢和胰岛素抵抗的影响。方法 SD雄鼠10只予普饲喂养作为空白对照组,30只经高脂饮食诱导成功的DIO雄鼠随机分为肥胖对照组、二甲双胍组、有氧运动+平肥方干预组,每组10只。实验干预6周后,检测各组大鼠体质量(BW)、空腹血糖(FPG)、总胆固醇(TCH)、甘油三酯(TG)、极低密度脂蛋白(VLDL)、空腹胰岛素(FINS)、HOMA-指数(HOMA-index)等。结果与对照组比较,DIO大鼠体质量、脂代谢各指标、血糖、胰岛素等差异具有统计学意义(P<0.01);干预数周后,与肥胖对照组比较,二甲双胍组和综合组均可显著降低DIO大鼠体质量,并可显著改善脂代谢诸指标及血糖、胰岛素及HOMA-指数(P<0.05或P<0.01)。其中,综合组在改善DIO大鼠体质量、VLDL两指标更优于二甲双胍治疗组(P<0.05)。结论 DIO大鼠普遍存在体质量、脂代谢异常及胰岛素抵抗;有氧运动和中药平肥方结合干预DIO大鼠,相对二甲双胍,在改善胰岛素抵抗的同时,能更好地减轻体质量并改善脂质代谢。Objective To evaluate the effect of combined therapeutic of aerobic exercise and Pingfeifang on lipid metabolism and insulin resistant of diet-induced-obesity （DIO） rats. Methods 10 SD male rats used for blank contrast group, while 30 DIO male rats were divided into DIO group, mclbine group and combined therapeutic of aerobic exercise and Pingfeifang group （therapeutic group）, each group has 10 rats. Aider 6 weeks intervening, the rats body weight（BW）, fasting plasma glucose （FPG）, total cholesterol （TCH）, triglyceride（TG）, very low density lipoprotein （VLDL）, fast insulin （FINS）, HOMA-Index were tested. Results Comparing to the blank contrast group fed with normal chow, the BW, FPG,TCH, TG, VLDL, FINS and HOMA-index were higher in DIO group（P〈0.01）. Comparing to DIO group, the melbine group and therapeutic group have reduced body weight, and improved FPG,TCH,TG,VLDL,FINS and HOMA-index （P〈0.05 or P〈0.01）. And for the body weight and VLDL, the therapeutic group have better effect than those in melbine group （P〈0.05）. Conclusion DIO rats have heavier body weight, abnormal lipid metabolism and insulin resistant. Comparing to melbine group, therapeutic group have more satisfied effects on reducing the body weight and improved lipid metabolism and insulin resistant.

关 键 词：DIO 肥胖 胰岛素抵抗 游泳/平肥方 

分 类 号：R589[医药卫生—内分泌]