松龄血脉康胶囊改善高血压患者血管顺应性和血管内皮功能的临床研究  

The clinical research of song ling xue mai kangameliorating the compliance and endothelial function of artery in hypertensive patients

作　　者：翁锦龙[1] 郑直[1] 

机构地区：[1]福建中医药大学附属人民医院,福建福州350004

出　　处：《湖南中医药大学学报》2011年第8期62-64,共3页Journal of Hunan University of Chinese Medicine

摘　　要：目的观察松龄血脉康改善血管顺应性和血管内皮功能的功效。方法选取患者90例,随机分为2组,对照组(45例,常规西药治疗)、治疗组(45例,常规西药治疗+松龄血脉康胶囊),疗程均为12周。结果治疗组C-FPWV较治疗前明显下降(P<0.01),对照组C-FPWV较治疗前也明显下降(P<0.05),两组比较,治疗组C-FPWV下降幅度明显优于对照组(P<0.01)。治疗组与对照组FDM较治疗前明显下降(P<0.01),两组比较,治疗组FDM下降幅度明显优于对照组(P<0.01)。治疗前后血压及症状分级变化,治疗组与对照组治疗前后血压及症状分级较治疗前明显下降(P<0.01)。结论松龄血脉康与降压药联合,可有效改善血管顺应性及内皮功能,较之单用降压药具有明显的临床意义,且可以更好地稳定血压与改善症状。Objective To observe the effect of song ling xue mai kang on blood vessel compliance and endothelial function.Methods the 90 patients with essential hypertension were randomly divided into control group（n=45） treated with hydrochlorothiazide and irbesartan and treatment group（n--45） treated with hydrochlorothiazide, irbesartan and song ling xue mai kang for 12 weeks.Results C-FPWV was decreased in treatment group（P〈0.01） and control group（P〈0.05）.And compared with control group,C-FPWV was lower in treatment group（P〈0.01）.FDM was reduced in treatment group and control group（P〈0.01 respectively）.And FDM was lower in treatment group than that in control group（P〈0.01）. Blood pressure and grade of symptom were declined in control group（P〈0.01 ） and treatment group（P〈0.01）. And compared with control group, blood pressure and grade of symptom were lower in treatment group（P〈0.01）.Conclusion Combined with Song ling xue mai kang and antihypertensive drug, it is effective to ameliorate the compliance and endothelial function of artery in hypertensive patients, which is better to control blood pressure and improve symptom than antihypertensive drug only.

关 键 词：松龄血脉康胶囊 动脉脉搏波速度 血流介导的血管舒张反应 高血压 氢氯噻嗪 厄贝沙坦 

分 类 号：R544.1[医药卫生—心血管疾病]