橙皮苷对糖尿病大鼠心泵功能和心率变异性的影响  

The effect of hesperidin on cardiac pumping function and heart rate variability of diabetic rat

作　　者：王巍[1] 杨智昉[2] 王红卫[2] 张颖[2] 李慈珍[2] 刘远谋[2] 曹久妹[1] 赵咏桔[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院老年病科,上海200025 [2]上海交通大学医学院生理教研室,上海200025

出　　处：《内科理论与实践》2011年第4期291-294,共4页Journal of Internal Medicine Concepts & Practice

基　　金：上海市教育委员会基金(项目编号:05B212);上海市科学技术委员会基金(项目编号:06JC14045)

摘　　要：目的:研究橙皮苷对链佐星(STZ)诱发的糖尿病大鼠心泵功能和心率变异性(HRV)的影响并初步探讨其作用机制。方法:30只大鼠随机分为对照组(n=6)、糖尿病组(n=12)和橙皮苷治疗组(n=12)。运用Langerdorff灌流糖尿病鼠离体心脏HRV功率谱分析等方法,观察橙皮苷对糖尿病大鼠的心脏收缩力、冠状动脉(冠脉)流量、心电图QRS波及HRV的影响。结果:橙皮苷10×10-6 mol/L可增加离体大鼠心脏冠脉流量106.0%,并使心肌收缩力增加87.3%,QRS波宽缩短33.3%。糖尿病鼠的心率加快,窦性RR间期的标准差(SDNN)减小,交感神经、迷走神经紧张性低频/高频比(LF/HF)增大,而橙皮苷处理后,心率、SDNN和LF/HF值均有所恢复。结论:橙皮苷可改善STZ诱发糖尿病大鼠的冠脉循环和心泵功能,并逆转由糖尿病引起的HRV变化。Objective To study the effects and mechanism of hesperidin on the pumping function of streptozotocin induced diabetic rat heart. Methods Thirty rats were randomly divided into three groups： control （n=6）, diabetic （n=12） and hesperidin-treated（n=12）groups. Diabetes was induced by streptozotocin. Langendorff perfusion system on isolated heart and heart rate variability （HRV） analysis were used to study the effect of hesperidin on cardiac contractility, coronary artery blood flow, QRS wave of electrocardiography and HRV. Results Hesperidin 10×lO^-6 mol/L could increase the coronary blood flow and contractility of the diabetic rat heart by 106.0% and 87.3%, respectively; meanwhile it shortened the QRS wave by 33.3%. In diabetic rats, the heart rate increased, standard deviation of sinus RR intervals （SDNN）decreased and ratio of sympathetic and vagal tone （LF/HF）inereased. All these three parameters recovered somewhat after treated with hesperidin. Conclusions Hesperidin could improve the coronary blood flow and heart pumping function of streptozotocin induced diabetic rat heart and could reverse the changes of HRV produced by diabetes as well.

关 键 词：糖尿病 橙皮苷 心率变异 心泵功能 

分 类 号：R285.5[医药卫生—中药学]