小牛血去蛋白提取物眼凝胶治疗浅层点状角膜炎临床观察  

The clinical observation of protein-free calf blood extract eye gel for treatment of superficial punctate keratitis

作　　者：汤静[1] 韩宇[1] 蒲一民[1] 

机构地区：[1]乐山市人民医院眼科,四川乐山614000

出　　处：《西部医学》2011年第8期1498-1499,共2页Medical Journal of West China

摘　　要：目的观察小牛血去蛋白提取物眼凝胶对浅层点状角膜炎(SPK)患者角膜上皮修复的影响,评价其疗效和安全性。方法 124例确诊为SPK患者,随机分为观察组与对照组,均观察单眼。两组同用0.1%氟米龙眼液、玻璃酸钠眼液滴眼,观察组加用小牛血去蛋白提取物眼凝胶。分别观察两组治疗前、治疗后1、2、3周症状改善情况、角膜上皮染色评分、视力评分,比较两组疗效。结果治疗1周后,观察组症状明显改善,角膜上皮染色评分、视力评分组间差异有显著性(P<0.05)。治疗3周时观察组治愈率88.7%,对照组71.0%,组间疗效亦有差异(P<0.05)。结论小牛血去蛋白提取物眼凝胶治疗SPK能快速有效改善不适症状,加速角膜上皮愈合,具有修复、营养、润滑作用,能明显提高疗效。所有患者均无不良反应,其治疗安全有效。Objective To evaluate the clinical effect of protein-free calf blood extract eye gel for superficial punctate keratitis.Methods 124 cases of superficial punctate keratitis were randomly divided into two groups： observation and control groups.Both of them were treated by fluorometholone eye drops（4times/d×2ws,2times/d×1w）sodium hyaluronate eye drops（4times/d×3ws）,and protein-free calf blood extract eye gel（4times/d×3ws）for observation group additionally.The clinical symptoms,corneal epithelium staining and visual acuity were observed before and 1 week,2 weeks and 3 weeks after treatments.Results 1 week after treatment,symptoms were improved in observation group,there was significant difference in corneal epithelium staining and visual acuity between two groups（P0.05）.3 weeks after treatment,cure rate 88.7% in observation group,71.0% in control group.Conclusion The protein-free calf blood extract eye gel can promote corneal epithelia healing,is effective and safe in treatment of superficial punctate keratitis.

关 键 词：点状角膜炎 药物治疗 小牛血去蛋白提取物眼凝胶 

分 类 号：R961[医药卫生—药理学]