IgA肾病患者肾组织中血管内皮生长因子与内皮素-1蛋白的表达  

Expressions of VEGF and ET-1 in renal tissue of patients with IgA nephropathy

作　　者：邢国兰[1] 孙军伟[1] 葛秀峰[2] 

机构地区：[1]郑州大学第一附属医院肾内科,郑州450052 [2]郑州大学司法鉴定中心,郑州450052

出　　处：《郑州大学学报（医学版）》2011年第4期590-592,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:检测IgA肾病患者肾组织中血管内皮生长因子(VEGF)与内皮素-1(ET-1)的表达。方法:采用免疫组化染色方法检测52例有血管病变的IgA肾病患者(A组)、38例无血管病变的IgA肾病患者(B组)及48例微小病变肾小球病患者(C组)肾组织中VEGF与ET-1的表达。结果:A、B、C组患者肾组织中VEGF蛋白的阳性表达率分别为94.2%、10.5%和4.2%,ET-1蛋白的阳性表达率分别为98.1%、13.2%和6.3%,3组相比,差异有统计学意义(χ2=103.281和104.760,P均<0.001)。A、B、C组患者中VEGF与ET-1蛋白的表达有关联性(rP=0.566,0.628,0.377,P<0.05)。结论:VEGF、ET-1在IgA肾病进展中可能发挥重要作用,可作为判断预后及干预治疗的重要指标。Aim：To investigate the expressions of vascular endothelial growth factor（VEGF）and endothelin-1（ET-1）in renal tissue of patients with IgA nephropathy.Methods：The expressions of VEGF and ET-1 in renal tissue from 52 cases of IgA nephropathy with vascular lesions（group A）,38 cases of IgA nephropathy without vascular lesions（group B）,and 48 cases of minimal change glomerulonephropathy（group C）were detected by immunohistochemical staining method.Results：The expression rates of VEGF in group A,B,and C were 94.2%,10.5% and 4.2%,meanwhile,the expression rates of ET-1 were 98.1%,13.2% and 6.3%,and there were significant differences in the expression rates of VEGF and ET-1 among the 3 groups（χ2=103.281 and 104.760,P0.001）.The expression of VEGF was associated with that of ET-1 in group A,B,and C（rP=0.566,0.628,0.377,P0.05）.Conclusion：VEGF and ET-1 may play an important role in the progression of IgA nephropathy,which could be used as the indicators of prognosis and treatment.

关 键 词：血管内皮生长因子 内皮素-1 IGA肾病 血管病变 

分 类 号：R692.3[医药卫生—泌尿科学]