盐酸舍曲林片对抑郁的稳定期COPD患者6分钟步行试验的影响  

Influences of Sertraline Hydrochloride Tablets in patients with stable chronic obstructive pulmonary disease accompanied with depression in 6-minute walk test

作　　者：何远强[1] 刘海琴[1] 葛晓红[1] 杨晓梅[1] 杨素花[1] 曹刚[1] 

机构地区：[1]徐州医学院附属淮安医院呼吸科,江苏淮安223002

出　　处：《临床肺科杂志》2011年第9期1340-1342,共3页Journal of Clinical Pulmonary Medicine

基　　金：江苏省淮安市S科技支撑计划(社会发展)HAS2009001-3

摘　　要：目的探讨盐酸舍曲林片对抑郁的稳定期慢性阻塞性肺疾病患者6 min步行试验的影响。方法将120例抑郁的稳定期慢性阻塞性肺疾病患者随机分为常规组和实验组,常规组仅实施常规的治疗,实验组除给予常规的治疗,还给予盐酸舍曲林片口服抗抑郁治疗,5周后行6 min步行试验,试验前后记录患者的血压、心率及呼吸频率,采用美国GEMPremier3000型血气分析仪测定血气结果,所有患者均测定肺功能。结果实验组和常规组在6 min步行试验距离、动脉血氧饱和度下降分数、血乳酸浓度方面,差异均具有显著性,6 min步行距离同FEV1、FEV1/FVC正相关,动脉血氧饱和度下降分数同FEV1、FEV1/FVC比值呈明显负相关(P<0.05)。结论盐酸舍曲林片能改善抑郁的慢性阻塞性肺疾病患者的6 min步行距离,提高运动耐力。Objective To investigate the Influences of Sertraline Hydrochloride Tablets in patients with stable chronic obstructive pulmonary disease accompanied with depression in 6-minute walk test.Methods 120 patients with chronic obstructive pulmonary disease accompanied with depression were randomly divided into conventional group and experimental group,conventional group were only given conventional treatments,while experimental experimental experimental experimental group were given Sertraline Hydrochloride Tablets additionally.6-minute walk test were evaluated in patients after 5 weeks,Blood pressure,heart rates and respiratory rates were recorded before and after testing,arterial blood gas were measured by the U.S.GEM Premier3000 blood gas analyzer,lung function were measured in all patients.Results Comparing to the conventional group,there were significantly differences in the distance of 6-minute walk test,degression fraction of arterial oxygen saturation,blood lactate concentration.the distance of 6-minute walk test were positively correlated with FEV1 and FEV1/FVC,degression fraction of arterial oxygen saturation were negatively correlated with FEV1 and FEV1/FVC（P0.05）.Conclusions Sertraline Hydrochloride Tablets can improve the distance of 6-minute walk test in patients with stable chronic obstructive pulmonary disease accompanied with depression,and increase the endurance of sports.

关 键 词：6min步行试验 慢性阻塞性肺疾病 抑郁 盐酸舍曲林片 

分 类 号：R563.9[医药卫生—呼吸系统]