老年2型糖尿病患者并发肺部感染多因素分析  

Multivariate analysis in Elderly type 2 diabetes mellitus patients with pulmonary infection

作　　者：周国庆[1] 付鹏[1] 李爽[2] 杨文[3] 

机构地区：[1]广西壮族自治区南溪山医院老年病科,广西桂林541002 [2]广西壮族自治区南溪山医院检验科,广西桂林541002 [3]广西壮族自治区南溪山医院影像科,广西桂林541002

出　　处：《临床肺科杂志》2011年第9期1372-1374,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究探讨老年2型糖尿病患者并发肺部感染的因素及其危险因素。方法对我院2001年1月至2010年1月收治的2型糖尿病并发肺部感染老年患者89例,单纯随机选取同期无并发肺部感染2型糖尿病老年患者107例,对其临床资料进行回顾性研究。结果将23种影响因素进行单因素分析,其中有9种因素差异具有显著性,这些因素分别为:血糖控制不良、肺功能不良、全血黏度(低切)、胆固醇、免疫球蛋白IgG、β2微球蛋白、D二聚体、T细胞亚群(CD4++/CD8++活性)、NK细胞活性减少,将单因素分析中差别具有显著意义的9个变量再进行Logistic多因素回归分析,只有血糖控制不良、肺功能不良、β2微球蛋白、T细胞亚群(CD4++/CD8++活性)减少、NK细胞活性减少是独立危险因素。结论控制血糖、改善肺功能状况、降低β2微球蛋白含量、提高T细胞亚群(CD4++/CD8++活性)及NK细胞活性对预防老年2型糖尿病患者并发肺部感染有较高的临床意义。Objective To investigate the elderly type 2 diabetic patients with pulmonary infection in multi-factor and its risk factors.Methods From January 2001 to January 2010 89 cases with type 2 diabetes mellitus in elderly patients with pulmonary infection were treated,and in the same period 107 elderly patients with type 2 diabetes mellitus were randomly selected without pulmonary infection were retrospectively researched with its pathologic data,laboratory data,imaging data,clinical data.Results We found that there were nine factors in patients with pulmonary infection has significant differences with that of patients without pulmonary infection when taken the 23 affecting factors into the single-factor analysis.The nine factors were poor control of blood glucose,bad pulmonary function,whole blood viscosity（low shear）,cholesterol,immunoglobulin IgG,β2-microglobulin,D-dimer,T cell subsets decreasing and NK cell subsets decreasing.When taken the nine variables into further Logistic multivariate regression analysis,we found that only poor control of blood glucose,bad pulmonary function,β2-microglobulin,T cell subsets（activity of CD＋4/CD＋8） decreasing and NK cell subsets decreasing are independent risk factors in elderly type 2 diabetic patients with pulmonary infection.Conclusion It＇s important for us to control the blood glucose,improve pulmonary function,decrease β2 microglobulin,and improve the activity of CD＋4/CD＋8 of T cell subsets and NK cell for elderly type 2 diabetic patients with pulmonary infection.

关 键 词：2型糖尿病 肺部感染 危险因素 LOGISTIC回归 

分 类 号：R587.1[医药卫生—内分泌]